Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042349755> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3042349755 endingPage "352" @default.
- W3042349755 startingPage "349" @default.
- W3042349755 abstract "In the 1980s the first results of an early multilevel contracture release (MLCR) in patients suffering from progressive Duchenne muscular dystrophy (DMD) showed a positive effect on ambulation. Despite the demonstrated positive effects of prolongation of walking this treatment is not part of current guidelines. The aim of our study was to evaluate the effect of MLCR as well as its combination with glucocorticoid (GC) treatment on ambulation.Data of all boys (n = 86) with DMD treated in our outpatient department were analyzed regarding the treatment and loss of independent ambulation. In all, 23 were treated with GC only, ten were operated on, 21 received GC and underwent MLCR and 32 received neither of the two treatments.The analysis of the loss of independent ambulation in our cohort showed a comparable extension of the ambulatory period between the GC-treated and MLCR-treated boys (p = 0.008 and p = 0.005, respectively). Furthermore, an additive effect of both therapies was found; patients with DMD who had both treatments were able to walk two years longer than those with only one of the two treatment options (p<0.001).Standard GC treatment and early MLCR in lower limbs have an independent positive effect on prolongation of ambulation in patients with DMD. In our cohort, the combination of both therapies is significantly more effective than each therapy alone. We suggest both should be offered to all DMD patients eligible.Level of evidence: III." @default.
- W3042349755 created "2020-07-23" @default.
- W3042349755 creator A5014234631 @default.
- W3042349755 creator A5036074260 @default.
- W3042349755 creator A5055445723 @default.
- W3042349755 creator A5069052158 @default.
- W3042349755 creator A5087432997 @default.
- W3042349755 date "2020-08-01" @default.
- W3042349755 modified "2023-10-03" @default.
- W3042349755 title "Positive effect of the combination of multilevel contracture release and glucocorticoid treatment in Duchenne muscular dystrophy" @default.
- W3042349755 cites W1578877692 @default.
- W3042349755 cites W1963597100 @default.
- W3042349755 cites W1967535039 @default.
- W3042349755 cites W2004367874 @default.
- W3042349755 cites W2034978086 @default.
- W3042349755 cites W2064216106 @default.
- W3042349755 cites W2073481346 @default.
- W3042349755 cites W2088924855 @default.
- W3042349755 cites W2089305683 @default.
- W3042349755 cites W2170273074 @default.
- W3042349755 cites W2408953691 @default.
- W3042349755 cites W2431474207 @default.
- W3042349755 cites W2767327591 @default.
- W3042349755 cites W2784992484 @default.
- W3042349755 cites W2894576922 @default.
- W3042349755 doi "https://doi.org/10.1302/1863-2548.14.200033" @default.
- W3042349755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7453179" @default.
- W3042349755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32874370" @default.
- W3042349755 hasPublicationYear "2020" @default.
- W3042349755 type Work @default.
- W3042349755 sameAs 3042349755 @default.
- W3042349755 citedByCount "2" @default.
- W3042349755 countsByYear W30423497552022 @default.
- W3042349755 countsByYear W30423497552023 @default.
- W3042349755 crossrefType "journal-article" @default.
- W3042349755 hasAuthorship W3042349755A5014234631 @default.
- W3042349755 hasAuthorship W3042349755A5036074260 @default.
- W3042349755 hasAuthorship W3042349755A5055445723 @default.
- W3042349755 hasAuthorship W3042349755A5069052158 @default.
- W3042349755 hasAuthorship W3042349755A5087432997 @default.
- W3042349755 hasBestOaLocation W30423497551 @default.
- W3042349755 hasConcept C126322002 @default.
- W3042349755 hasConcept C141071460 @default.
- W3042349755 hasConcept C1862650 @default.
- W3042349755 hasConcept C2776937108 @default.
- W3042349755 hasConcept C2778943923 @default.
- W3042349755 hasConcept C2779030066 @default.
- W3042349755 hasConcept C2780841215 @default.
- W3042349755 hasConcept C35785553 @default.
- W3042349755 hasConcept C71924100 @default.
- W3042349755 hasConcept C72563966 @default.
- W3042349755 hasConceptScore W3042349755C126322002 @default.
- W3042349755 hasConceptScore W3042349755C141071460 @default.
- W3042349755 hasConceptScore W3042349755C1862650 @default.
- W3042349755 hasConceptScore W3042349755C2776937108 @default.
- W3042349755 hasConceptScore W3042349755C2778943923 @default.
- W3042349755 hasConceptScore W3042349755C2779030066 @default.
- W3042349755 hasConceptScore W3042349755C2780841215 @default.
- W3042349755 hasConceptScore W3042349755C35785553 @default.
- W3042349755 hasConceptScore W3042349755C71924100 @default.
- W3042349755 hasConceptScore W3042349755C72563966 @default.
- W3042349755 hasIssue "4" @default.
- W3042349755 hasLocation W30423497551 @default.
- W3042349755 hasLocation W30423497552 @default.
- W3042349755 hasLocation W30423497553 @default.
- W3042349755 hasLocation W30423497554 @default.
- W3042349755 hasOpenAccess W3042349755 @default.
- W3042349755 hasPrimaryLocation W30423497551 @default.
- W3042349755 hasRelatedWork W1605697680 @default.
- W3042349755 hasRelatedWork W1991626129 @default.
- W3042349755 hasRelatedWork W2046400425 @default.
- W3042349755 hasRelatedWork W2416696094 @default.
- W3042349755 hasRelatedWork W2602380447 @default.
- W3042349755 hasRelatedWork W3042349755 @default.
- W3042349755 hasRelatedWork W3094596692 @default.
- W3042349755 hasRelatedWork W3165929540 @default.
- W3042349755 hasRelatedWork W4234652181 @default.
- W3042349755 hasRelatedWork W4285734827 @default.
- W3042349755 hasVolume "14" @default.
- W3042349755 isParatext "false" @default.
- W3042349755 isRetracted "false" @default.
- W3042349755 magId "3042349755" @default.
- W3042349755 workType "article" @default.