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- W3042350830 endingPage "24" @default.
- W3042350830 startingPage "1" @default.
- W3042350830 abstract "Spermatogonial stem cells (SSCs) are generally characterized by excellent DNA surveillance and repair, resulting in one of the lowest spontaneous mutation rates in the body. However, the barriers to mutagenesis can be overwhelmed under two sets of circumstances. First, replication errors may generate age-dependent mutations that provide the mutant cells with a selective advantage, leading to the clonal expansions responsible for dominant genetic diseases such as Apert syndrome and achondroplasia. The second mechanism centers on the vulnerability of the male germline to oxidative stress and the induction of oxidative DNA damage in spermatozoa. Defective repair of such oxidative damage in the fertilized oocyte results in the creation of mutations in the zygote that can influence the health and well-being of the offspring. A particular hot spot for such oxidative attack on chromosome 15 has been found to align with several mutations responsible for paternally mediated disease, including cancer, psychiatric disorders, and infertility." @default.
- W3042350830 created "2020-07-23" @default.
- W3042350830 creator A5031666155 @default.
- W3042350830 creator A5066498990 @default.
- W3042350830 creator A5088651676 @default.
- W3042350830 date "2020-11-23" @default.
- W3042350830 modified "2023-09-27" @default.
- W3042350830 title "The Sins of Our Forefathers: Paternal Impacts on De Novo Mutation Rate and Development" @default.
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