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- W304236433 abstract "To determine the safety and efficacy of radionuclide instillation to cystic brain tumors the authors instilled radioactive chromic phosphate in 6 patients. Three patients had craniopharyngioma, 2 had Grade IV astrocytoma and 1 had Grade II astrocytoma. A dose calculated to give 20,000 rads to the cyst wall per instillation was used. One of the 3 patients with craniopharyngioma had 2 instillations, the remaining 2 patients had 1 instillation each. The 2 patients with Grade IV astrocytoma had 3 instillations each. Only 1 instillation was done on the lone patient with Grade II astrocytoma. The P32 given to achieve this dose ranged from .11 mCi to 2.5 mCi. The cyst volumes ranged from 2 to 44 cc's. Radionuclide leakage was not detected in either the CNS or the reticuloendothelial systems by bremstrahlung scanning. Stereotactic instillation was done in the majority of cases, in others a free hand instillation was done through an existing trephine hole or a cerebral perfusion reservoir. The frequency of cyst fluid aspiration in three patients with craniopharyngioma decreased post instillation. All 3 patients with craniopharyngioma are alive at the time of this report. In the 2 patients with Grade IV astrocytoma a reduction in cyst size more » and frequency of cyst aspiration was noted. No adverse effects were noted in any of our patients at the time of instillation or thereafter. They conclude that P32 instillation by stereotactic or free hand method is a safe and possibly beneficial procedure for both types of brain tumors. « less" @default.
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- W304236433 date "1985-05-01" @default.
- W304236433 modified "2023-09-26" @default.
- W304236433 title "Treatment of cystic grade IV astrocytoma and crainopharyngioma with radioactive phosphorus - A preliminary report" @default.
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