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• W3042404641 abstract "Abstract Retinal ganglion cell (RGC) replacement and optic nerve regeneration hold potential for restoring vision lost to optic neuropathy. Following transplantation, RGCs must integrate into the neuroretinal circuitry in order to receive afferent visual signals for processing and transmission to central targets. To date, the efficiency of RGC retinal integration following transplantation has been limited. We sought to characterize spontaneous interactions between transplanted human embryonic stem cell-derived RGCs and the recipient mature mammalian retina, and to identify and overcome barriers to the structural integration of transplanted neurons. Using an in vitro model system, following transplantation directly onto the inner surface of organotypic mouse retinal explants, human RGC somas form compact clusters and extend bundled neurites that remain superficial to the neural retinal tissue, hindering any potential for afferent synaptogenesis. To enhance integration, we explored methods to increase the cellular permeability of the internal limiting membrane (ILM). Digestion of extracellular matrix components using proteolytic enzymes was titrated to achieve disruption of the ILM while minimizing retinal toxicity and preserving endogenous retinal glial reactivity. Such ILM disruption is associated with dispersion rather than clustering of transplanted RGC bodies and neurites, and with a marked increase in transplanted RGC neurite extension into retinal parenchyma. The ILM appears to be a barrier to afferent retinal connectivity by transplanted RGCs and its circumvention may be necessary for successful functional RGC replacement through transplantation." @default.
• W3042404641 created "2020-07-23" @default.
• W3042404641 creator A5010388452 @default.
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• W3042404641 date "2020-07-14" @default.
• W3042404641 modified "2023-09-25" @default.
• W3042404641 title "Structural engraftment and topographic spacing of transplanted human stem cell-derived retinal ganglion cells" @default.
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• W3042404641 cites W2002103394 @default.
• W3042404641 cites W2003437721 @default.
• W3042404641 cites W2003994112 @default.
• W3042404641 cites W2004538934 @default.
• W3042404641 cites W2008442745 @default.
• W3042404641 cites W2011634069 @default.
• W3042404641 cites W2019492982 @default.
• W3042404641 cites W2024846396 @default.
• W3042404641 cites W2031599833 @default.
• W3042404641 cites W2040848874 @default.
• W3042404641 cites W2048338614 @default.
• W3042404641 cites W2049763161 @default.
• W3042404641 cites W2049956106 @default.
• W3042404641 cites W2054859767 @default.
• W3042404641 cites W2057266151 @default.
• W3042404641 cites W2057502749 @default.
• W3042404641 cites W2070628315 @default.
• W3042404641 cites W2087238430 @default.
• W3042404641 cites W2087898838 @default.
• W3042404641 cites W2091698674 @default.
• W3042404641 cites W2104230245 @default.
• W3042404641 cites W2117547777 @default.
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• W3042404641 cites W2143550055 @default.
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• W3042404641 cites W2156303270 @default.
• W3042404641 cites W2160605010 @default.
• W3042404641 cites W2161258143 @default.
• W3042404641 cites W2161602638 @default.
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• W3042404641 cites W2168599434 @default.
• W3042404641 cites W2261622256 @default.
• W3042404641 cites W2318035006 @default.
• W3042404641 cites W2326860902 @default.
• W3042404641 cites W2408411305 @default.
• W3042404641 cites W2409724652 @default.
• W3042404641 cites W2414627912 @default.
• W3042404641 cites W2460681702 @default.
• W3042404641 cites W2466697085 @default.
• W3042404641 cites W2495536352 @default.
• W3042404641 cites W2527991441 @default.
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• W3042404641 cites W2537731554 @default.
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• W3042404641 cites W2561655264 @default.
• W3042404641 cites W2570769191 @default.
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• W3042404641 cites W2792623181 @default.
• W3042404641 cites W2794925059 @default.
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• W3042404641 cites W2893675751 @default.
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• W3042404641 cites W2956625420 @default.
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• W3042404641 doi "https://doi.org/10.1101/2020.07.14.196055" @default.
• W3042404641 hasPublicationYear "2020" @default.
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