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- W3042436639 endingPage "1894" @default.
- W3042436639 startingPage "1894" @default.
- W3042436639 abstract "Locally advanced rectal cancer (LARC) response to neoadjuvant chemoradiotherapy (nCRT) is very heterogeneous and up to 30% of patients are considered non-responders, presenting no tumor regression after nCRT. This study aimed to determine the ability of pre-treatment T2-weighted based radiomics features to predict LARC non-responders. A total of 67 LARC patients who underwent a pre-treatment MRI followed by nCRT and total mesorectal excision were assigned into training (n = 44) and validation (n = 23) groups. In both datasets, the patients were categorized according to the Ryan tumor regression grade (TRG) system into non-responders (TRG = 3) and responders (TRG 1 and 2). We extracted 960 radiomic features/patient from pre-treatment T2-weighted images. After a three-step feature selection process, including LASSO regression analysis, we built a radiomics score with seven radiomics features. This score was significantly higher among non-responders in both training and validation sets (p < 0.001 and p = 0.03) and it showed good predictive performance for LARC non-response, achieving an area under the curve (AUC) = 0.94 (95% CI: 0.82–0.99) in the training set and AUC = 0.80 (95% CI: 0.58–0.94) in the validation group. The multivariate analysis identified the radiomics score as an independent predictor for the tumor non-response (OR = 6.52, 95% CI: 1.87–22.72). Our results indicate that MRI radiomics features could be considered as potential imaging biomarkers for early prediction of LARC non-response to neoadjuvant treatment." @default.
- W3042436639 created "2020-07-23" @default.
- W3042436639 creator A5001972988 @default.
- W3042436639 creator A5018335241 @default.
- W3042436639 creator A5022189057 @default.
- W3042436639 creator A5048619287 @default.
- W3042436639 creator A5074660435 @default.
- W3042436639 creator A5077330147 @default.
- W3042436639 date "2020-07-14" @default.
- W3042436639 modified "2023-09-26" @default.
- W3042436639 title "Pre-Treatment T2-WI Based Radiomics Features for Prediction of Locally Advanced Rectal Cancer Non-Response to Neoadjuvant Chemoradiotherapy: A Preliminary Study" @default.
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- W3042436639 doi "https://doi.org/10.3390/cancers12071894" @default.
- W3042436639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7409205" @default.
- W3042436639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32674345" @default.
- W3042436639 hasPublicationYear "2020" @default.
- W3042436639 type Work @default.