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- W3042458246 abstract "Significance The loading of the core Mcm2-7 helicase onto origin DNA is essential for the formation of replication forks and genomic stability. Here, we report two cryo-electron microscopy (cryo-EM) structures that capture helicase loader–helicase complexes just prior to DNA insertion. These pre-loading structures, combined with a computational simulation of the dynamic transition from the pre-loading state to the loaded state, provide crucial insights into the mechanism required for topologically linking the helicase to DNA. The helicase loading system is highly conserved from yeast to human, which means that the molecular principles described here for the yeast system are likely applicable to the human system." @default.
- W3042458246 created "2020-07-23" @default.
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- W3042458246 date "2020-07-15" @default.
- W3042458246 modified "2023-10-06" @default.
- W3042458246 title "Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6" @default.
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- W3042458246 doi "https://doi.org/10.1073/pnas.2006231117" @default.
- W3042458246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7395460" @default.
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