Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042469989> ?p ?o ?g. }
- W3042469989 endingPage "12289" @default.
- W3042469989 startingPage "12275" @default.
- W3042469989 abstract "The RNA interference (RNAi) process encompasses the cellular mechanisms by which short-noncoding RNAs posttranscriptionally modulate gene expression. First discovered in 1998, today RNAi represents the foundation underlying complex biological mechanisms that are dysregulated in many diseases. MicroRNAs are effector molecules of gene silencing in RNAi, and their modulation can lead to a wide response in cells. Enoxacin was reported as the first and unique small-molecule enhancer of microRNA (SMER) maturation. Herein, the biological activity of enoxacin as SMER is discussed to shed light on its innovative mode of action, its potential in treating different diseases, and the feasibility of using enoxacin as a chemical template for inspiring medicinal chemists. We debate its mechanism of action at the molecular level and the possible impact on future ligand and/or structure-guided chemical optimizations, as well as opportunities and drawbacks associated with the development of quinolones such as SMERs." @default.
- W3042469989 created "2020-07-23" @default.
- W3042469989 creator A5001818513 @default.
- W3042469989 creator A5020731665 @default.
- W3042469989 creator A5043864360 @default.
- W3042469989 date "2020-07-16" @default.
- W3042469989 modified "2023-10-16" @default.
- W3042469989 title "Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs" @default.
- W3042469989 cites W1647075334 @default.
- W3042469989 cites W1648301895 @default.
- W3042469989 cites W1941480039 @default.
- W3042469989 cites W1966402618 @default.
- W3042469989 cites W1972966887 @default.
- W3042469989 cites W1987824810 @default.
- W3042469989 cites W1988165397 @default.
- W3042469989 cites W1988358888 @default.
- W3042469989 cites W1989634026 @default.
- W3042469989 cites W1991563094 @default.
- W3042469989 cites W1992384033 @default.
- W3042469989 cites W2000496185 @default.
- W3042469989 cites W2000554351 @default.
- W3042469989 cites W2001416012 @default.
- W3042469989 cites W2006247279 @default.
- W3042469989 cites W2013842709 @default.
- W3042469989 cites W2021169961 @default.
- W3042469989 cites W2021580236 @default.
- W3042469989 cites W2023166679 @default.
- W3042469989 cites W2030300755 @default.
- W3042469989 cites W2031465545 @default.
- W3042469989 cites W2032588457 @default.
- W3042469989 cites W2040237389 @default.
- W3042469989 cites W2044967196 @default.
- W3042469989 cites W2050613411 @default.
- W3042469989 cites W2056406429 @default.
- W3042469989 cites W2056573404 @default.
- W3042469989 cites W2062890651 @default.
- W3042469989 cites W2064131445 @default.
- W3042469989 cites W2071282345 @default.
- W3042469989 cites W2076624411 @default.
- W3042469989 cites W2076941373 @default.
- W3042469989 cites W2087972419 @default.
- W3042469989 cites W2087975583 @default.
- W3042469989 cites W2093419384 @default.
- W3042469989 cites W2105549148 @default.
- W3042469989 cites W2107101690 @default.
- W3042469989 cites W2109227959 @default.
- W3042469989 cites W2138291262 @default.
- W3042469989 cites W2138501360 @default.
- W3042469989 cites W2138664009 @default.
- W3042469989 cites W2139703680 @default.
- W3042469989 cites W2160467221 @default.
- W3042469989 cites W2176669036 @default.
- W3042469989 cites W2177926460 @default.
- W3042469989 cites W2253239516 @default.
- W3042469989 cites W2292422784 @default.
- W3042469989 cites W2418959584 @default.
- W3042469989 cites W2466393177 @default.
- W3042469989 cites W2560195344 @default.
- W3042469989 cites W2576456099 @default.
- W3042469989 cites W2591349253 @default.
- W3042469989 cites W2592799068 @default.
- W3042469989 cites W2617873512 @default.
- W3042469989 cites W2650005198 @default.
- W3042469989 cites W2749532133 @default.
- W3042469989 cites W2752688411 @default.
- W3042469989 cites W2761500998 @default.
- W3042469989 cites W2771049305 @default.
- W3042469989 cites W2776565218 @default.
- W3042469989 cites W2782360860 @default.
- W3042469989 cites W2788693636 @default.
- W3042469989 cites W2792039041 @default.
- W3042469989 cites W2796747562 @default.
- W3042469989 cites W2800371883 @default.
- W3042469989 cites W2806828400 @default.
- W3042469989 cites W2809052371 @default.
- W3042469989 cites W2810651359 @default.
- W3042469989 cites W2884394723 @default.
- W3042469989 cites W2898588691 @default.
- W3042469989 cites W2909313584 @default.
- W3042469989 cites W2909502867 @default.
- W3042469989 cites W2909797466 @default.
- W3042469989 cites W2915731678 @default.
- W3042469989 cites W2917329184 @default.
- W3042469989 cites W2920438880 @default.
- W3042469989 cites W2941332364 @default.
- W3042469989 cites W2947124871 @default.
- W3042469989 cites W2947244263 @default.
- W3042469989 cites W2950104589 @default.
- W3042469989 cites W2950275691 @default.
- W3042469989 cites W2952150493 @default.
- W3042469989 cites W4211041983 @default.
- W3042469989 cites W4252392290 @default.
- W3042469989 doi "https://doi.org/10.1021/acs.jmedchem.0c00510" @default.
- W3042469989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8009507" @default.
- W3042469989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32672457" @default.
- W3042469989 hasPublicationYear "2020" @default.
- W3042469989 type Work @default.
- W3042469989 sameAs 3042469989 @default.