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- W3042499068 endingPage "112533" @default.
- W3042499068 startingPage "112533" @default.
- W3042499068 abstract "We have prepared a series of ten 3-arylcoumarin molecules, their respective fac-[Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L⁀L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to the fac-[Re(CO)3]+ core, most of the resulting complexes showed remarkable antibacterial potency. Several rhenium complexes exhibit activity in nanomolar concentrations against Gram-positive pathogens such as Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA) and Enterococcus faecium. The molecules do not affect bacterial cell membrane potential, but some of the most potent complexes strongly interact with DNA, indicating it as a possible target for their mode of action. In vivo studies in the zebrafish model showed that the complexes with anti-staphylococcal/MRSA activity were non-toxic to the organism even at much higher doses of the corresponding MICs. In the zebrafish-MRSA infection model, the complexes increased the survival rate of infected fish up to 100% and markedly reduced bacterial burden. Moreover, all rescued fish developed normally following the treatments with the metallic compounds." @default.
- W3042499068 created "2020-07-23" @default.
- W3042499068 creator A5000099476 @default.
- W3042499068 creator A5007122055 @default.
- W3042499068 creator A5050548956 @default.
- W3042499068 creator A5058569801 @default.
- W3042499068 creator A5073122524 @default.
- W3042499068 creator A5083685126 @default.
- W3042499068 creator A5091887037 @default.
- W3042499068 date "2020-11-01" @default.
- W3042499068 modified "2023-09-24" @default.
- W3042499068 title "Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)" @default.
- W3042499068 cites W1481153882 @default.
- W3042499068 cites W1615535881 @default.
- W3042499068 cites W1710731033 @default.
- W3042499068 cites W1752217747 @default.
- W3042499068 cites W1918519540 @default.
- W3042499068 cites W1948791258 @default.
- W3042499068 cites W1969360633 @default.
- W3042499068 cites W1981353016 @default.
- W3042499068 cites W1985966274 @default.
- W3042499068 cites W1989761771 @default.
- W3042499068 cites W1999596860 @default.
- W3042499068 cites W2000061453 @default.
- W3042499068 cites W2008724643 @default.
- W3042499068 cites W2015723183 @default.
- W3042499068 cites W2017473714 @default.
- W3042499068 cites W2017843558 @default.
- W3042499068 cites W2021324145 @default.
- W3042499068 cites W2021541661 @default.
- W3042499068 cites W2023956656 @default.
- W3042499068 cites W2028793394 @default.
- W3042499068 cites W2044591029 @default.
- W3042499068 cites W2048375137 @default.
- W3042499068 cites W2050480585 @default.
- W3042499068 cites W2051160325 @default.
- W3042499068 cites W2054526986 @default.
- W3042499068 cites W2056815096 @default.
- W3042499068 cites W2058739913 @default.
- W3042499068 cites W2062394005 @default.
- W3042499068 cites W2063708990 @default.
- W3042499068 cites W2066982769 @default.
- W3042499068 cites W2072181067 @default.
- W3042499068 cites W2081811484 @default.
- W3042499068 cites W2085432374 @default.
- W3042499068 cites W2086707171 @default.
- W3042499068 cites W2098072562 @default.
- W3042499068 cites W2101444285 @default.
- W3042499068 cites W2108433768 @default.
- W3042499068 cites W2112850441 @default.
- W3042499068 cites W2115806935 @default.
- W3042499068 cites W2116816819 @default.
- W3042499068 cites W2117075429 @default.
- W3042499068 cites W2119995276 @default.
- W3042499068 cites W2126978003 @default.
- W3042499068 cites W2128531001 @default.
- W3042499068 cites W2131818949 @default.
- W3042499068 cites W2132454074 @default.
- W3042499068 cites W2133768972 @default.
- W3042499068 cites W2139693058 @default.
- W3042499068 cites W2141023795 @default.
- W3042499068 cites W2142664741 @default.
- W3042499068 cites W2146247522 @default.
- W3042499068 cites W2147723850 @default.
- W3042499068 cites W2150090472 @default.
- W3042499068 cites W2262860928 @default.
- W3042499068 cites W2303190122 @default.
- W3042499068 cites W2316276133 @default.
- W3042499068 cites W2318985175 @default.
- W3042499068 cites W2324126391 @default.
- W3042499068 cites W2324411030 @default.
- W3042499068 cites W2325648398 @default.
- W3042499068 cites W2334138351 @default.
- W3042499068 cites W2334576785 @default.
- W3042499068 cites W2461371449 @default.
- W3042499068 cites W2523113134 @default.
- W3042499068 cites W2558941103 @default.
- W3042499068 cites W2731658008 @default.
- W3042499068 cites W2746050631 @default.
- W3042499068 cites W2762035445 @default.
- W3042499068 cites W2765346922 @default.
- W3042499068 cites W2766261689 @default.
- W3042499068 cites W2766419891 @default.
- W3042499068 cites W2766862411 @default.
- W3042499068 cites W2793020835 @default.
- W3042499068 cites W2799775155 @default.
- W3042499068 cites W2801909459 @default.
- W3042499068 cites W2884538472 @default.
- W3042499068 cites W2887719629 @default.
- W3042499068 cites W2896418674 @default.
- W3042499068 cites W2919520691 @default.
- W3042499068 cites W2921440531 @default.
- W3042499068 cites W2925017120 @default.
- W3042499068 cites W2931980759 @default.
- W3042499068 cites W2932584663 @default.
- W3042499068 cites W2936122769 @default.
- W3042499068 cites W2943185265 @default.
- W3042499068 cites W2947614150 @default.