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- W3042551279 abstract "Introduction:Treatment efficacy of radiation therapy using Yttrium-90 radionuclide is evaluated by thebremsstrahlung SPECT imaging following radiation therapy. The radioisotopic images have the ability to provide reliable activity map of 90Y distribution. But these images have a low quantitative accuracy in the 90Y bremsstrahlung SPECT imaging, therefore the optimization of some imaging important indicators i.e. the energy window width and collimatorgeometry, which heavily affect acquisition images quality, is necessary. The aim of thispaper is to estimate the effects of the energy window width and the hole diameter of a MEcollimator on the image contrast of the 90Y bremsstrahlung SPECT images obtained usingSIMIND Monte Carlo simulation program and improve image quality which could be usedto estimate activity distribution after radiation therapy.Materials and Methods:In this paper we simulated the SPECT system and a Jaszczak phantom consist of six hotspheres in different diameters by use of the SIMIND Monte Carlo simulation program tostudy 90Y SPECT images by assessment of the holes diameter of a ME collimator including2.35, 2.59, 2.82, 2.94, 3.06 and 3.3 mm with fixed values of the collimator and septathicknesses (3.2 cm and 1.14mm, respectively) in the two energy windows including 60-160 keV and 60-400 keV. SPECT imaging protocol is selected according to the clinical study.An activity of 1.5GBq 90Y was considered for the hot spheres without background activity.We used OS-EM algorithm to reconstruct projections and evaluated the contrast of thereconstructed images of six hot spheres of Jaszczak phantom with selection of proper ROIs.Results: The comparison of the images contrast of Jaszczak phantom spheres indicated thatgenerally with increasing the hole diameter of collimator, the images contrast of thespheres were decreased. In order to, in comparison to the 1st energy window (60–160 keV),the 2nd energy window (60-400 keV) was increased the image contrast. The results showedthat for a fixed collimator and septa thickness values (3.2 cm and 1.14mm, respectively),the optimal value of the hole diameter was found 2.35 mm. Also from the stand point of theimage contrast, the optimal energy window was found ranging from 60 to 400 keV.Conclusion:By use of the evaluation of the images contrast of Jaszczak phantom by SIMIND Monte Carlosimulation study, the best contrast is obtained when by use of the wide energy windowranging from 60 to 400 keV, which increased the imaging system sensitivity and decreasedvariance of the activity estimation. Moreover, a ME collimator with fixed values of 3.2 cmand 1.14 mm for the collimator and septa thicknesses, respectively and a hole diameter of2.35 mm can improve the 90Y activity estimation and provide a suitable image quality forthe 90Y bremsstrahlung SPECT imaging." @default.
- W3042551279 created "2020-07-23" @default.
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- W3042551279 date "2018-12-01" @default.
- W3042551279 modified "2023-09-23" @default.
- W3042551279 title "Optimization of Bremsstrahlung imaging in Yttrium internal radiation therapy" @default.
- W3042551279 doi "https://doi.org/10.22038/ijmp.2018.13142" @default.
- W3042551279 hasPublicationYear "2018" @default.
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