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- W3042558051 abstract "Integration of transposable elements into the genome is mutagenic. Mechanisms targeting integrations into relatively safe locations, hence minimizing deleterious consequences for cell fitness, have emerged during evolution. In budding yeast, integration of the Ty1 LTR retrotransposon upstream of RNA polymerase III (Pol III)-transcribed genes requires interaction between Ty1 integrase (IN1) and AC40, a subunit common to Pol I and Pol III. Here, we identify the Ty1 targeting domain of IN1 that ensures (i) IN1 binding to Pol I and Pol III through AC40, (ii) IN1 genome-wide recruitment to Pol I- and Pol III-transcribed genes, and (iii) Ty1 integration only at Pol III-transcribed genes, while IN1 recruitment by AC40 is insufficient to target Ty1 integration into Pol I-transcribed genes. Swapping the targeting domains between Ty5 and Ty1 integrases causes Ty5 integration at Pol III-transcribed genes, indicating that the targeting domain of IN1 alone confers Ty1 integration site specificity." @default.
- W3042558051 created "2020-07-23" @default.
- W3042558051 creator A5000909890 @default.
- W3042558051 creator A5016315152 @default.
- W3042558051 creator A5017299673 @default.
- W3042558051 creator A5018836753 @default.
- W3042558051 creator A5019811686 @default.
- W3042558051 creator A5047159510 @default.
- W3042558051 creator A5052972676 @default.
- W3042558051 creator A5074317515 @default.
- W3042558051 creator A5078147441 @default.
- W3042558051 creator A5086580823 @default.
- W3042558051 date "2020-07-17" @default.
- W3042558051 modified "2023-10-14" @default.
- W3042558051 title "A small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes" @default.
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