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- W3042562010 abstract "Mitochondrial transfer has been recognized to play a role in a variety of processes, ranging from fertilization to cancer and neurodegenerative diseases as well as mammalian horizontal gene transfer. It is achieved through either exogeneous or intercellular mitochondrial transfer. From the viewpoint of evolution, exogeneous mitochondrial transfer is quite akin to the initial process of symbiosis between α-protobacterium and archaea, although the progeny have developed more sophisticated machinery to engulf environmental materials, including nutrients, bacteria, and viruses. A molecular-based knowledge of endocytosis, including macropinocytosis and endosomal escape involving bacteria and viruses, could provide mechanistic insights into exogeneous mitochondrial transfer. We focus on exogeneous mitochondrial transfer in this review to facilitate the clinical development of the use of isolated mitochondria to treat various pathological conditions. Several kinds of novel procedures to enhance exogeneous mitochondrial transfer have been developed and are summarized in this review." @default.
- W3042562010 created "2020-07-23" @default.
- W3042562010 creator A5049187397 @default.
- W3042562010 creator A5073581014 @default.
- W3042562010 date "2020-07-15" @default.
- W3042562010 modified "2023-10-02" @default.
- W3042562010 title "From Cell Entry to Engraftment of Exogenous Mitochondria" @default.
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