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• W3042600382 abstract "The 2019 novel coronavirus, declared a pandemic, has infected 2.6 million people as of April 27, 2020, and has resulted in the death of 181,938 people. d -dimer is an important prognostic tool, is often elevated in patients with severe coronavirus disease-19 (COVID-19) infection and in those who suffered death. In this systematic review, we aimed to investigate the prognostic role of d -dimer in COVID-19-infected patients. We searched PubMed, Medline, Embase, Ovid, and Cochrane for studies reporting admission d -dimer levels in COVID-19 patients and its effect on mortality. Eighteen studies (16 retrospective and 2 prospective) with a total of 3682 patients met the inclusion criteria. The pooled weighted mean difference (WMD) demonstrated significantly elevated d -dimer levels in patients who died versus those who survived (WMD, 6.13 mg/L; 95% confidence interval [CI] 4.16–8.11; P < 0.001). Similarly, the pooled mean d -dimer levels were significantly elevated in patients with severe COVID-19 infection (WMD, 0.54 mg/L; 95% CI 0.28–0.80; P < 0.001). The risk of mortality was fourfold higher in patients with positive d -dimer versus negative d -dimer (risk ratio, 4.11; 95% CI, 2.48–6.84; P < 0.001) and the risk of developing severe disease was twofold higher in patients with positive d -dimer levels versus negative d -dimer (risk ratio, 2.04; 95% CI, 1.34–3.11; P < 0.001). Our meta-analysis demonstrates that patients with COVID-19 infection presenting with elevated d -dimer levels have an increased risk of severe disease and mortality." @default.
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• W3042600382 date "2020-07-02" @default.
• W3042600382 modified "2023-10-16" @default.
• W3042600382 title "Elevated d-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019" @default.
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• W3042600382 doi "https://doi.org/10.1097/crd.0000000000000330" @default.
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