Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042609691> ?p ?o ?g. }
- W3042609691 abstract "Abstract Ras dimerization is critical for Raf activation, yet Ras alone does not dimerize. Here we show that the Ras binding domain of Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid bilayers and, to a lesser extent, in solution as observed by size exclusion chromatography and confirmed by SAXS. Community network analysis based on molecular dynamics (MD) simulations show robust allosteric connections linking the two Raf-RBD D113 residues, located in the Galectin scaffold protein binding site of each Raf-RBD molecule and 85 Å apart on opposite ends of the dimer complex. Our results suggest that Raf-RBD binding and Ras dimerization are concerted events that lead to a high-affinity signaling complex at the membrane that we propose is an essential unit in the macromolecular assembly of higher order Ras/Raf/Galectin complexes important for signaling through the Ras/Raf/MEK/ERK pathway." @default.
- W3042609691 created "2020-07-23" @default.
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- W3042609691 date "2020-07-15" @default.
- W3042609691 modified "2023-09-26" @default.
- W3042609691 title "Raf promotes dimerization of the Ras G-domain with increased allosteric connections" @default.
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- W3042609691 doi "https://doi.org/10.1101/2020.07.15.205070" @default.
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