Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042625264> ?p ?o ?g. }
- W3042625264 abstract "Proton-coupled monocarboxylate transporters (MCTs), representing the first four isoforms of the SLC16A gene family, mainly participate in the transport of lactate, pyruvate and other monocarboxylates. Cancer cells exhibit a metabolic shift from oxidative metabolism to an enhanced glycolytic phenotype, leading to a higher production of lactate in the cytoplasm. Excessive accumulation of lactate threatens the survival of cancer cells, and the overexpression of proton-coupled MCTs observed in multiple types of cancer facilitates enhanced export of lactate from highly glycolytic cancer cells. Proton-coupled MCTs not only play critical roles in the metabolic symbiosis between hypoxic and normoxic cancer cells within tumors but also mediate metabolic interaction between cancer cells and cancer-associated stromal cells. Of the four proton-coupled MCTs, MCT1 and MCT4 are the predominantly expressed isoforms in cancer and have been identified as potential therapeutic targets in cancer. Therefore, in this review, we primarily focus on the roles of MCT1 and MCT4 in the metabolic reprogramming of cancer cells under hypoxic and nutrient-deprived conditions. Additionally, we discuss how MCT1 and MCT4 serve as metabolic links between cancer cells and cancer-associated stromal cells via transport of crucial monocarboxylates, as well as present emerging opportunities and challenges in targeting MCT1 and MCT4 for cancer treatment." @default.
- W3042625264 created "2020-07-23" @default.
- W3042625264 creator A5019614275 @default.
- W3042625264 creator A5025732261 @default.
- W3042625264 creator A5039412958 @default.
- W3042625264 creator A5040538229 @default.
- W3042625264 creator A5045301566 @default.
- W3042625264 creator A5067130875 @default.
- W3042625264 creator A5075448214 @default.
- W3042625264 creator A5076977780 @default.
- W3042625264 creator A5084560885 @default.
- W3042625264 creator A5086686905 @default.
- W3042625264 creator A5087592842 @default.
- W3042625264 date "2020-07-17" @default.
- W3042625264 modified "2023-10-15" @default.
- W3042625264 title "Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential" @default.
- W3042625264 cites W1964959571 @default.
- W3042625264 cites W1965393351 @default.
- W3042625264 cites W1970002473 @default.
- W3042625264 cites W1996507796 @default.
- W3042625264 cites W1997596656 @default.
- W3042625264 cites W1997722072 @default.
- W3042625264 cites W1998166655 @default.
- W3042625264 cites W1998976350 @default.
- W3042625264 cites W2002923467 @default.
- W3042625264 cites W2017007251 @default.
- W3042625264 cites W2020369202 @default.
- W3042625264 cites W2020988957 @default.
- W3042625264 cites W2049584121 @default.
- W3042625264 cites W2060669952 @default.
- W3042625264 cites W2060878129 @default.
- W3042625264 cites W2060934232 @default.
- W3042625264 cites W2061123122 @default.
- W3042625264 cites W2062459035 @default.
- W3042625264 cites W2063632665 @default.
- W3042625264 cites W2064689563 @default.
- W3042625264 cites W2068045057 @default.
- W3042625264 cites W2069279091 @default.
- W3042625264 cites W2073274327 @default.
- W3042625264 cites W2084377042 @default.
- W3042625264 cites W2095539104 @default.
- W3042625264 cites W2117117246 @default.
- W3042625264 cites W2120861043 @default.
- W3042625264 cites W2122372985 @default.
- W3042625264 cites W2127675410 @default.
- W3042625264 cites W2132053398 @default.
- W3042625264 cites W2135964373 @default.
- W3042625264 cites W2154152918 @default.
- W3042625264 cites W2164499983 @default.
- W3042625264 cites W2252382072 @default.
- W3042625264 cites W2297957816 @default.
- W3042625264 cites W2331669280 @default.
- W3042625264 cites W2403467521 @default.
- W3042625264 cites W2434407168 @default.
- W3042625264 cites W2519020116 @default.
- W3042625264 cites W2522974751 @default.
- W3042625264 cites W2580610814 @default.
- W3042625264 cites W2604433773 @default.
- W3042625264 cites W2604465118 @default.
- W3042625264 cites W2727838564 @default.
- W3042625264 cites W2740694596 @default.
- W3042625264 cites W2746285571 @default.
- W3042625264 cites W2750551733 @default.
- W3042625264 cites W2750558982 @default.
- W3042625264 cites W2756202814 @default.
- W3042625264 cites W2763966161 @default.
- W3042625264 cites W2763979809 @default.
- W3042625264 cites W2765515956 @default.
- W3042625264 cites W2771058495 @default.
- W3042625264 cites W2789833191 @default.
- W3042625264 cites W2790658373 @default.
- W3042625264 cites W2790821623 @default.
- W3042625264 cites W2790858728 @default.
- W3042625264 cites W2797429263 @default.
- W3042625264 cites W2885682258 @default.
- W3042625264 cites W2889488326 @default.
- W3042625264 cites W2898195249 @default.
- W3042625264 cites W2899450154 @default.
- W3042625264 cites W2899935963 @default.
- W3042625264 cites W2901019624 @default.
- W3042625264 cites W2901163162 @default.
- W3042625264 cites W2901386374 @default.
- W3042625264 cites W2901939398 @default.
- W3042625264 cites W2905085764 @default.
- W3042625264 cites W2915134459 @default.
- W3042625264 cites W2917730151 @default.
- W3042625264 cites W2952783314 @default.
- W3042625264 cites W2953879474 @default.
- W3042625264 cites W2977508467 @default.
- W3042625264 cites W2986321771 @default.
- W3042625264 cites W2999911931 @default.
- W3042625264 doi "https://doi.org/10.3389/fcell.2020.00651" @default.
- W3042625264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7379837" @default.
- W3042625264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32766253" @default.
- W3042625264 hasPublicationYear "2020" @default.
- W3042625264 type Work @default.
- W3042625264 sameAs 3042625264 @default.
- W3042625264 citedByCount "34" @default.
- W3042625264 countsByYear W30426252642020 @default.
- W3042625264 countsByYear W30426252642021 @default.