FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042653276> ?p ?o ?g. }

• W3042653276 endingPage "101645" @default.
• W3042653276 startingPage "101645" @default.
• W3042653276 abstract "Abstract Air pollution containing particulate matter (PM) less than 2.5 μm (PM2.5) plays an essential role in regulating hepatic disease. However, its molecular mechanism is not yet clear, lacking effective therapeutic strategies. In this study, we attempted to investigate the effects and mechanisms of PM2.5 exposure on hepatic injury by the in vitro and in vivo experiments. At first, we found that PM2.5 incubation led to a significant reduction of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), along with markedly reduced expression of different anti-oxidants. Notably, suppressor of IKKe (SIKE), known as a negative regulator of the interferon pathway, was decreased in PM2.5-incubated cells, accompanied with increased activation of TANK-binding kinase 1 (TBK1) and nuclear factor-κB (NF-κB). The in vitro studies showed that Nrf2 positively regulated SIKE expression under the conditions with or without PM2.5. After PM2.5 treatment, Nrf2 knockdown further accelerated SIEK decrease and TBK1/NF-κB activation, and opposite results were observed in cells with Nrf2 over-expression. Subsequently, the gene loss- and gain-function analysis demonstrated that SIKE deficiency further aggravated inflammation and TBK1/NF-κB activation caused by PM2.5, which could be abrogated by SIKE over-expression. Importantly, SIKE-alleviated inflammation was mainly dependent on TBK1 activation. The in vivo studies confirmed that SIKE- and Nrf2-knockout mice showed significantly accelerated hepatic injury after long-term PM2.5 exposure through reducing inflammatory response and oxidative stress. Juglanin (Jug), mainly isolated from Polygonum aviculare, exhibits anti-inflammatory and anti-oxidant effects. We found that Jug could increase Nrf2 activation, and then up-regulated SIKE in cells and liver tissues, mitigating PM2.5-induced liver injury. Together, all these data demonstrated that Nrf2 might positively meditate SIKE to inhibit inflammatory and oxidative damage, ameliorating PM2.5-induced liver injury. Jug could be considered as an effective therapeutic strategy against this disease by improving Nrf2/SIKE signaling pathway." @default.
• W3042653276 created "2020-07-23" @default.
• W3042653276 creator A5001433537 @default.
• W3042653276 creator A5017078233 @default.
• W3042653276 creator A5018626623 @default.
• W3042653276 creator A5027813231 @default.
• W3042653276 creator A5031665005 @default.
• W3042653276 creator A5035200384 @default.
• W3042653276 creator A5050459409 @default.
• W3042653276 creator A5051968569 @default.
• W3042653276 creator A5056893217 @default.
• W3042653276 creator A5063831306 @default.
• W3042653276 creator A5064390765 @default.
• W3042653276 creator A5069718154 @default.
• W3042653276 creator A5069771802 @default.
• W3042653276 creator A5076590004 @default.
• W3042653276 creator A5083247969 @default.
• W3042653276 creator A5084959058 @default.
• W3042653276 creator A5085212865 @default.
• W3042653276 creator A5086127329 @default.
• W3042653276 creator A5088583952 @default.
• W3042653276 date "2020-09-01" @default.
• W3042653276 modified "2023-10-18" @default.
• W3042653276 title "Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin" @default.
• W3042653276 cites W1455485982 @default.
• W3042653276 cites W1965359074 @default.
• W3042653276 cites W1979297771 @default.
• W3042653276 cites W1997021349 @default.
• W3042653276 cites W2001433854 @default.
• W3042653276 cites W2013393935 @default.
• W3042653276 cites W2031004071 @default.
• W3042653276 cites W2083387782 @default.
• W3042653276 cites W2085203929 @default.
• W3042653276 cites W2093373662 @default.
• W3042653276 cites W2113458136 @default.
• W3042653276 cites W2113702645 @default.
• W3042653276 cites W2116237065 @default.
• W3042653276 cites W2139484367 @default.
• W3042653276 cites W2146558971 @default.
• W3042653276 cites W2146571394 @default.
• W3042653276 cites W2339552406 @default.
• W3042653276 cites W2401030213 @default.
• W3042653276 cites W2473417829 @default.
• W3042653276 cites W2515048983 @default.
• W3042653276 cites W2625435459 @default.
• W3042653276 cites W2735263829 @default.
• W3042653276 cites W2758941402 @default.
• W3042653276 cites W2767432874 @default.
• W3042653276 cites W2767508571 @default.
• W3042653276 cites W2771140415 @default.
• W3042653276 cites W2778677617 @default.
• W3042653276 cites W2790686664 @default.
• W3042653276 cites W2799540422 @default.
• W3042653276 cites W2886966010 @default.
• W3042653276 cites W2888001952 @default.
• W3042653276 cites W2893204964 @default.
• W3042653276 cites W2896928442 @default.
• W3042653276 cites W2901586729 @default.
• W3042653276 cites W2914678709 @default.
• W3042653276 cites W2922353834 @default.
• W3042653276 cites W2944474168 @default.
• W3042653276 cites W2954592608 @default.
• W3042653276 cites W2967577775 @default.
• W3042653276 cites W2967958595 @default.
• W3042653276 cites W2970831802 @default.
• W3042653276 cites W2972010540 @default.
• W3042653276 cites W2987555622 @default.
• W3042653276 cites W2989982619 @default.
• W3042653276 cites W2990950052 @default.
• W3042653276 cites W2991372059 @default.
• W3042653276 cites W2996895663 @default.
• W3042653276 cites W2997542383 @default.
• W3042653276 cites W3003349514 @default.
• W3042653276 cites W3005168191 @default.
• W3042653276 cites W3006747521 @default.
• W3042653276 cites W3006784121 @default.
• W3042653276 cites W3011557946 @default.
• W3042653276 cites W3011617071 @default.
• W3042653276 cites W3011848203 @default.
• W3042653276 cites W3014631621 @default.
• W3042653276 cites W3015623909 @default.
• W3042653276 cites W3016045544 @default.
• W3042653276 cites W3034384544 @default.
• W3042653276 doi "https://doi.org/10.1016/j.redox.2020.101645" @default.
• W3042653276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7387847" @default.
• W3042653276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32863207" @default.
• W3042653276 hasPublicationYear "2020" @default.
• W3042653276 type Work @default.
• W3042653276 sameAs 3042653276 @default.
• W3042653276 citedByCount "26" @default.
• W3042653276 countsByYear W30426532762020 @default.
• W3042653276 countsByYear W30426532762021 @default.
• W3042653276 countsByYear W30426532762022 @default.
• W3042653276 countsByYear W30426532762023 @default.
• W3042653276 crossrefType "journal-article" @default.
• W3042653276 hasAuthorship W3042653276A5001433537 @default.
• W3042653276 hasAuthorship W3042653276A5017078233 @default.
• W3042653276 hasAuthorship W3042653276A5018626623 @default.

• next