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• W3042703508 abstract "Epileptic seizures often develop in 40–70 % of glioma patients and have a significant impact on patients’ quality of life. Many biomarkers have been suggested to be associated with glioma-related preoperative seizures (GPS). The purpose of the present study was to investigate the possible correlation between GPS and clinicopathological factors and a wide range of glioma-associated molecular markers (GMMs). First, a retrospective cohort study of 442 patients with glioma was evaluated at the PLA General Hospital. Univariate and multivariate logistic analyses were used to identify basic factors associated with GPS. Second, 40 pairs of cases who underwent deep sequencing of 68 GMMs were selected from both groups for in-depth analysis. Of the 442 patients examined in this study, 137 (31 %) had GPS. By analyzing the characteristics of these patients, the results showed that patient age (OR: 0.981, p = 0.037, 95 % CI: 0.964−0.999), WHO grade (OR: 0.678, p = 0.008, 95 % CI: 0.509−0.903) and IDH mutations (OR: 1.886, p = 0.013, 95 % CI: 1.143–3.11) in patients were associated with the occurrence of GPS. In our cohort, GPS did not differ by sex, tumor location, histopathological subtype, p53 expression, ARTX loss, MGMT gene promotor methylation, TERT promoter mutation, or 1p/19q co-deletion status. The results of the matching study showed that the paired groups had similar genetic expression profiles, and the mutation of these 68 GMMs was not correlated with the occurrence of GPS. The current study updates existing information on GPS and genetic markers in gliomas and explores the correlation of a wide range of GMMs and GPS. These factors may provide insights for developing effective treatment strategies aimed at seizure control." @default.
• W3042703508 created "2020-07-23" @default.
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• W3042703508 date "2020-10-01" @default.
• W3042703508 modified "2023-09-23" @default.
• W3042703508 title "Correlation of preoperative seizures with a wide range of tumor molecular markers in gliomas: An analysis of 442 glioma patients from China" @default.
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• W3042703508 doi "https://doi.org/10.1016/j.eplepsyres.2020.106430" @default.
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