FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042711090> ?p ?o ?g. }

• W3042711090 endingPage "20200292" @default.
• W3042711090 startingPage "20200292" @default.
• W3042711090 abstract "The rapid increase in critical thermal maximum (CT max ) in fish (or other animals) previously exposed to critically high temperature is termed ‘heat hardening’, which likely represents a key strategy to cope with increasingly extreme environments. The physiological mechanisms that determine acute thermal tolerance, and the underlying pathways facilitating heat hardening, remain debated. It has been posited, however, that exposure to high temperature is associated with tissue hypoxia and may be associated with the increased expression of hypoxia-inducible factor-1 (Hif-1). We studied acute thermal tolerance in zebrafish ( Danio rerio ) lacking functional Hif-1 α paralogs (Hif-1aa and Hif-1ab double knockout; Hif-1 α −/− ), which are known to exhibit markedly reduced hypoxia tolerance. We hypothesized that Hif-1 α −/− zebrafish would suffer reduced acute thermal tolerance relative to wild type and that the heat hardening ability would be lost. However, on the contrary, we observed that Hif-1 α −/− and wild-type fish did not differ in CT max , and both genotypes exhibited heat hardening of a similar degree when CT max was re-tested 48 h later. Despite exhibiting impaired hypoxia tolerance, Hif-1 α −/− zebrafish display unaltered thermal tolerance, suggesting that these traits are not necessarily functionally associated. Hif-1 α is accordingly not required for short-term acclimation in the form of heat hardening." @default.
• W3042711090 created "2020-07-23" @default.
• W3042711090 creator A5028844049 @default.
• W3042711090 creator A5060511977 @default.
• W3042711090 date "2020-07-01" @default.
• W3042711090 modified "2023-09-27" @default.
• W3042711090 title "Hypoxia inducible factor-1 <i>α</i> knockout does not impair acute thermal tolerance or heat hardening in zebrafish" @default.
• W3042711090 cites W1503900815 @default.
• W3042711090 cites W1604189153 @default.
• W3042711090 cites W1949101400 @default.
• W3042711090 cites W1971258591 @default.
• W3042711090 cites W1972781843 @default.
• W3042711090 cites W1981170407 @default.
• W3042711090 cites W1993712587 @default.
• W3042711090 cites W2012558229 @default.
• W3042711090 cites W2037590989 @default.
• W3042711090 cites W2040965579 @default.
• W3042711090 cites W2050086664 @default.
• W3042711090 cites W2051231578 @default.
• W3042711090 cites W2058124913 @default.
• W3042711090 cites W2059508094 @default.
• W3042711090 cites W2068292608 @default.
• W3042711090 cites W2077928306 @default.
• W3042711090 cites W2079476412 @default.
• W3042711090 cites W2080812076 @default.
• W3042711090 cites W2082455532 @default.
• W3042711090 cites W2085609942 @default.
• W3042711090 cites W2087377825 @default.
• W3042711090 cites W2121899528 @default.
• W3042711090 cites W2126098646 @default.
• W3042711090 cites W2135703418 @default.
• W3042711090 cites W2143343444 @default.
• W3042711090 cites W2144370436 @default.
• W3042711090 cites W2145352100 @default.
• W3042711090 cites W2153013358 @default.
• W3042711090 cites W2160571552 @default.
• W3042711090 cites W2166177997 @default.
• W3042711090 cites W2168909889 @default.
• W3042711090 cites W2171891743 @default.
• W3042711090 cites W2226989783 @default.
• W3042711090 cites W2229921310 @default.
• W3042711090 cites W2335287907 @default.
• W3042711090 cites W2508747100 @default.
• W3042711090 cites W2558744874 @default.
• W3042711090 cites W2616549989 @default.
• W3042711090 cites W2698223 @default.
• W3042711090 cites W2743646195 @default.
• W3042711090 cites W2755299846 @default.
• W3042711090 cites W2783539483 @default.
• W3042711090 cites W2801328486 @default.
• W3042711090 cites W2805504936 @default.
• W3042711090 cites W2908033575 @default.
• W3042711090 cites W2922293430 @default.
• W3042711090 cites W2950818918 @default.
• W3042711090 cites W2953761181 @default.
• W3042711090 cites W3028636183 @default.
• W3042711090 cites W40830852 @default.
• W3042711090 doi "https://doi.org/10.1098/rsbl.2020.0292" @default.
• W3042711090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7423049" @default.
• W3042711090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32673542" @default.
• W3042711090 hasPublicationYear "2020" @default.
• W3042711090 type Work @default.
• W3042711090 sameAs 3042711090 @default.
• W3042711090 citedByCount "13" @default.
• W3042711090 countsByYear W30427110902021 @default.
• W3042711090 countsByYear W30427110902022 @default.
• W3042711090 countsByYear W30427110902023 @default.
• W3042711090 crossrefType "journal-article" @default.
• W3042711090 hasAuthorship W3042711090A5028844049 @default.
• W3042711090 hasAuthorship W3042711090A5060511977 @default.
• W3042711090 hasBestOaLocation W30427110901 @default.
• W3042711090 hasConcept C104317684 @default.
• W3042711090 hasConcept C119406331 @default.
• W3042711090 hasConcept C160450060 @default.
• W3042711090 hasConcept C178790620 @default.
• W3042711090 hasConcept C185592680 @default.
• W3042711090 hasConcept C2776878037 @default.
• W3042711090 hasConcept C2779227376 @default.
• W3042711090 hasConcept C2780384893 @default.
• W3042711090 hasConcept C44255700 @default.
• W3042711090 hasConcept C540031477 @default.
• W3042711090 hasConcept C54355233 @default.
• W3042711090 hasConcept C7836513 @default.
• W3042711090 hasConcept C86803240 @default.
• W3042711090 hasConcept C95444343 @default.
• W3042711090 hasConceptScore W3042711090C104317684 @default.
• W3042711090 hasConceptScore W3042711090C119406331 @default.
• W3042711090 hasConceptScore W3042711090C160450060 @default.
• W3042711090 hasConceptScore W3042711090C178790620 @default.
• W3042711090 hasConceptScore W3042711090C185592680 @default.
• W3042711090 hasConceptScore W3042711090C2776878037 @default.
• W3042711090 hasConceptScore W3042711090C2779227376 @default.
• W3042711090 hasConceptScore W3042711090C2780384893 @default.
• W3042711090 hasConceptScore W3042711090C44255700 @default.
• W3042711090 hasConceptScore W3042711090C540031477 @default.
• W3042711090 hasConceptScore W3042711090C54355233 @default.
• W3042711090 hasConceptScore W3042711090C7836513 @default.
• W3042711090 hasConceptScore W3042711090C86803240 @default.

• next