Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042723013> ?p ?o ?g. }
- W3042723013 abstract "ABSTRACT Mitochondria and chloroplasts are organelles with high iron demand that are particularly susceptible to iron-induced oxidative stress. Despite the necessity of strict iron regulation in these organelles, much remains unknown about mitochondrial and chloroplast iron transport in plants. Here, we propose that Arabidopsis Ferroportin 3 (FPN3) is an iron exporter dual-targeted to mitochondria and chloroplasts. FPN3 is expressed in shoots regardless of iron conditions, but its transcripts accumulate under iron deficiency in roots. fpn3 mutants cannot grow as well as wild type under iron-deficient conditions and shoot iron levels are reduced in fpn3 mutants compared to wild type. ICP-MS measurements show that iron levels in the mitochondria and chloroplasts are increased relative to wild type, consistent with the proposed role of FPN3 as a mitochondrial/plastid iron exporter. In iron deficient fpn3 mutants, abnormal mitochondrial ultrastructure was observed, whereas chloroplast ultrastructure was not affected, implying that FPN3 plays a critical role in the mitochondria. Overall, our study suggests that FPN3 is essential for optimal iron homeostasis. Significance statement Iron homeostasis must be tightly controlled in the mitochondria and chloroplasts, but iron trafficking in these organelles is not fully understood. Our work suggests that FPN3 is an iron exporter required for maintaining proper iron levels in mitochondria and chloroplasts. Furthermore, FPN3 is necessary for the optimal growth and normal mitochondrial ultrastructure under iron deficiency. This study reveals the physiological role of FPN3 and advances our understanding of iron regulation in mitochondria and chloroplasts." @default.
- W3042723013 created "2020-07-23" @default.
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- W3042723013 date "2020-07-16" @default.
- W3042723013 modified "2023-09-27" @default.
- W3042723013 title "Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Arabidopsis" @default.
- W3042723013 cites W1523931961 @default.
- W3042723013 cites W1539503448 @default.
- W3042723013 cites W153972209 @default.
- W3042723013 cites W1570621366 @default.
- W3042723013 cites W1580812079 @default.
- W3042723013 cites W1584075170 @default.
- W3042723013 cites W1587581577 @default.
- W3042723013 cites W1589407229 @default.
- W3042723013 cites W1597130528 @default.
- W3042723013 cites W1674800848 @default.
- W3042723013 cites W1832410072 @default.
- W3042723013 cites W1967050491 @default.
- W3042723013 cites W1967140535 @default.
- W3042723013 cites W1968693263 @default.
- W3042723013 cites W1970544295 @default.
- W3042723013 cites W1970761716 @default.
- W3042723013 cites W1971070487 @default.
- W3042723013 cites W1972677973 @default.
- W3042723013 cites W1972998779 @default.
- W3042723013 cites W1978901208 @default.
- W3042723013 cites W1980400357 @default.
- W3042723013 cites W1982251843 @default.
- W3042723013 cites W1984364185 @default.
- W3042723013 cites W1989252944 @default.
- W3042723013 cites W1990465549 @default.
- W3042723013 cites W1992921638 @default.
- W3042723013 cites W1996046088 @default.
- W3042723013 cites W1997044263 @default.
- W3042723013 cites W1998519486 @default.
- W3042723013 cites W1999414181 @default.
- W3042723013 cites W2000262581 @default.
- W3042723013 cites W2002084790 @default.
- W3042723013 cites W2002900187 @default.
- W3042723013 cites W2003842357 @default.
- W3042723013 cites W2004525492 @default.
- W3042723013 cites W2015061479 @default.
- W3042723013 cites W2018282435 @default.
- W3042723013 cites W2024264388 @default.
- W3042723013 cites W2024801947 @default.
- W3042723013 cites W2026209459 @default.
- W3042723013 cites W2026352963 @default.
- W3042723013 cites W2028770228 @default.
- W3042723013 cites W2032230960 @default.
- W3042723013 cites W2035410822 @default.
- W3042723013 cites W2036366614 @default.
- W3042723013 cites W2037571192 @default.
- W3042723013 cites W2037737899 @default.
- W3042723013 cites W2039064403 @default.
- W3042723013 cites W2052675750 @default.
- W3042723013 cites W2053275942 @default.
- W3042723013 cites W2053427298 @default.
- W3042723013 cites W2053849251 @default.
- W3042723013 cites W2060804705 @default.
- W3042723013 cites W2063616227 @default.
- W3042723013 cites W2065796463 @default.
- W3042723013 cites W2068665675 @default.
- W3042723013 cites W2071069087 @default.
- W3042723013 cites W2071132061 @default.
- W3042723013 cites W2071137329 @default.
- W3042723013 cites W2073317899 @default.
- W3042723013 cites W2074004676 @default.
- W3042723013 cites W2079552583 @default.
- W3042723013 cites W2080025453 @default.
- W3042723013 cites W2082222828 @default.
- W3042723013 cites W2085238216 @default.
- W3042723013 cites W2090205132 @default.
- W3042723013 cites W2096451658 @default.
- W3042723013 cites W2096781728 @default.
- W3042723013 cites W2098115340 @default.
- W3042723013 cites W2100420410 @default.
- W3042723013 cites W2101222093 @default.
- W3042723013 cites W2105362350 @default.
- W3042723013 cites W2105683783 @default.
- W3042723013 cites W2106077509 @default.
- W3042723013 cites W2107734506 @default.
- W3042723013 cites W2107958361 @default.
- W3042723013 cites W2113764015 @default.
- W3042723013 cites W2114570899 @default.