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• W3042730014 endingPage "111595" @default.
• W3042730014 startingPage "111595" @default.
• W3042730014 abstract "Nrf2 is a transcription factor that regulates cytoprotective cellular responses to oxidative and electrophilic stress. Nrf2 is potently activated by the synthetic food additive, tert-butylhydroquinone (tBHQ), which is widely used as a preservative in oils and processed foods. Previously published studies have established that tBHQ has numerous effects on T cell function. The purpose of this study was to determine the effect of tBHQ on B cell function and the role of Nrf2 in these effects. Specifically, we investigated T cell-independent B cell activation, differentiation, and IgM antibody production. Murine wild-type and Nrf2-null splenocytes were isolated, treated with tBHQ (0.25-2.5 μm), and activated by lipopolysaccharide (LPS), a T cell-independent B cell activator. Our findings indicate that tBHQ significantly enhanced IgM production in activated wild-type, but not Nrf2-null, B cells, suggesting this effect is Nrf2-dependent. In contrast, tBHQ significantly decreased the induction of CD69, CD25, CD22, and CD138 in both wild-type and Nrf2-null splenocytes. These findings indicate that the tBHQ-mediated increase in IgM is Nrf2-dependent, whereas the inhibition of CD69, CD25, CD22 and CD138 is Nrf2-independent. Overall, this study demonstrates that in addition to its effects on T cells, tBHQ also has potent effects on T cell-independent B cell function." @default.
• W3042730014 created "2020-07-23" @default.
• W3042730014 creator A5009906973 @default.
• W3042730014 creator A5055298886 @default.
• W3042730014 date "2020-11-01" @default.
• W3042730014 modified "2023-10-12" @default.
• W3042730014 title "Nrf2-dependent and -independent effects of tBHQ in activated murine B cells" @default.
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• W3042730014 doi "https://doi.org/10.1016/j.fct.2020.111595" @default.
• W3042730014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7568862" @default.
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