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- W3042736523 abstract "Abstract The hallmarks of constitutive heterochromatin, HP1 and H3K9me2/3, assemble heterochromatin- like domains/complexes outside canonical constitutively heterochromatic territories where they regulate chromatin-templated processes. Domains are more than 100kb in size; complexes less than 100kb. They are present in the genomes of organisms ranging from fission yeast to man, with an expansion in size and number in mammals. Some of the likely functions of the domains/complexes include silencing of the donor mating type region in fission yeast, regulation of mammalian imprinted genes and the phylotypic progression during vertebrate development. Far cis - and trans -contacts between micro-phase separated domains/complexes in mammalian nuclei contribute to the emergence of epigenetic compartmental domains (ECDs) detected in Hi-C maps. We speculate that a thermodynamic description of micro-phase separation of heterochromatin- like domains/complexes will require a gestalt shift away from the monomer as the “ unit of incompatibility ”, where it is the choice of monomer that determines the sign and magnitude of the Flory-Huggins parameter, χ. Instead, a more dynamic structure, the oligo-nucleosomal “clutch”, consisting of between 2 to 10 nucleosomes is both the long sought-after secondary structure of chromatin and its unit of incompatibility. Based on this assumption we present a simple theoretical framework that enables an estimation of χ for domains/complexes flanked by euchromatin and thereby an indication of their tendency to phase separate. The degree of phase separation is specified by χN, where N is the number of “clutches” in a domain/complex. Our approach may provide an additional tool for understanding the biophysics of the 3D genome." @default.
- W3042736523 created "2020-07-23" @default.
- W3042736523 creator A5031982146 @default.
- W3042736523 creator A5040121652 @default.
- W3042736523 creator A5087394378 @default.
- W3042736523 date "2020-07-19" @default.
- W3042736523 modified "2023-09-25" @default.
- W3042736523 title "Biology and physics of heterochromatin-<i>like</i>domains/complexes" @default.
- W3042736523 cites W1426271323 @default.
- W3042736523 cites W144273846 @default.
- W3042736523 cites W1492110739 @default.
- W3042736523 cites W1506225011 @default.
- W3042736523 cites W1540173732 @default.
- W3042736523 cites W1768482373 @default.
- W3042736523 cites W1904090057 @default.
- W3042736523 cites W1912455695 @default.
- W3042736523 cites W1933423171 @default.
- W3042736523 cites W1968240088 @default.
- W3042736523 cites W1968622711 @default.
- W3042736523 cites W1969907628 @default.
- W3042736523 cites W1970473208 @default.
- W3042736523 cites W1970488458 @default.
- W3042736523 cites W1972373037 @default.
- W3042736523 cites W1973062929 @default.
- W3042736523 cites W1974047233 @default.
- W3042736523 cites W1974484497 @default.
- W3042736523 cites W1974930724 @default.
- W3042736523 cites W1976962550 @default.
- W3042736523 cites W1977637608 @default.
- W3042736523 cites W1978386737 @default.
- W3042736523 cites W1978883431 @default.
- W3042736523 cites W1979187818 @default.
- W3042736523 cites W1980738706 @default.
- W3042736523 cites W1981197560 @default.
- W3042736523 cites W1981659742 @default.
- W3042736523 cites W1982609730 @default.
- W3042736523 cites W1985036194 @default.
- W3042736523 cites W1985556762 @default.
- W3042736523 cites W1988635100 @default.
- W3042736523 cites W1989324954 @default.
- W3042736523 cites W1989582360 @default.
- W3042736523 cites W1990137409 @default.
- W3042736523 cites W1991716961 @default.
- W3042736523 cites W1993822465 @default.
- W3042736523 cites W1996287615 @default.
- W3042736523 cites W1996431759 @default.
- W3042736523 cites W1999027330 @default.
- W3042736523 cites W2000342325 @default.
- W3042736523 cites W2000423660 @default.
- W3042736523 cites W2000821622 @default.
- W3042736523 cites W2000826343 @default.
- W3042736523 cites W2004304977 @default.
- W3042736523 cites W2005136311 @default.
- W3042736523 cites W2009940298 @default.
- W3042736523 cites W2010383327 @default.
- W3042736523 cites W2011068062 @default.
- W3042736523 cites W2011181841 @default.
- W3042736523 cites W2012935454 @default.
- W3042736523 cites W2013939194 @default.
- W3042736523 cites W2014656425 @default.
- W3042736523 cites W2018363492 @default.
- W3042736523 cites W2019002796 @default.
- W3042736523 cites W2019127737 @default.
- W3042736523 cites W2019820997 @default.
- W3042736523 cites W2020782061 @default.
- W3042736523 cites W2021158547 @default.
- W3042736523 cites W2021183579 @default.
- W3042736523 cites W2021409414 @default.
- W3042736523 cites W2021462917 @default.
- W3042736523 cites W2022431828 @default.
- W3042736523 cites W2023474858 @default.
- W3042736523 cites W2026260746 @default.
- W3042736523 cites W2026501344 @default.
- W3042736523 cites W2026907845 @default.
- W3042736523 cites W2033800157 @default.
- W3042736523 cites W2034219651 @default.
- W3042736523 cites W2034501059 @default.
- W3042736523 cites W2034946403 @default.
- W3042736523 cites W2035726721 @default.
- W3042736523 cites W2035877973 @default.
- W3042736523 cites W2041278780 @default.
- W3042736523 cites W2041659028 @default.
- W3042736523 cites W2041860345 @default.
- W3042736523 cites W2044282102 @default.
- W3042736523 cites W2045090702 @default.
- W3042736523 cites W2048645295 @default.
- W3042736523 cites W2049846825 @default.
- W3042736523 cites W2052770408 @default.
- W3042736523 cites W2052842503 @default.
- W3042736523 cites W2062728251 @default.
- W3042736523 cites W2067724937 @default.
- W3042736523 cites W2068690942 @default.
- W3042736523 cites W2070224244 @default.
- W3042736523 cites W2072334434 @default.
- W3042736523 cites W2072466432 @default.
- W3042736523 cites W2073285188 @default.
- W3042736523 cites W2075805514 @default.
- W3042736523 cites W2076154138 @default.
- W3042736523 cites W2078955430 @default.
- W3042736523 cites W2080479776 @default.