FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042765400> ?p ?o ?g. }

• W3042765400 endingPage "2955" @default.
• W3042765400 startingPage "2939" @default.
• W3042765400 abstract "Laryngeal squamous cell carcinoma (LSCC) is one of the most commonly seen head and neck malignancies. Identifying potent markers and/or targets for early diagnosis and individualized therapies for LSCC remains a considerable challenge. The present study analyzed online data and identified lncRNA KRT16P2 as a significantly upregulated long non-coding RNA (lncRNA) in LSCC. KRT16P2 knockdown in LSCC cells inhibited cancer cell proliferation, invasion, and migration. Similar to KRT16P2, EGFR expression was also significantly upregulated in LSCC. KRT16P2 and EGFR were positively correlated in LSCC tissue samples. EGFR knockdown also dramatically inhibited LSCC cell proliferation and aggressiveness (invasion and migration). Through online data and online tools, miR-1294 was predicted to target KRT16P2 and EGFR 3'UTR simultaneously. KRT16P2 inhibited miR-1294 expression, and miR-1294 inhibited EGFR expression through direct binding. miR-1294 overexpression repressed LSCC cell proliferation and aggressiveness. The effects of KRT16P2 silence on the expression of EGFR, LSCC cell proliferation, invasion, and migration, the protein levels of ki-67, PCNA, and cleaved-Caspase 3, as well as the phosphorylation of AKT, were all significantly reversed by miR-1294 inhibition. In conclusion, we demonstrated a lncRNA KRT16P2/miR-1294/EGFR axis that regulates LSCC cell proliferation, invasion, and migration. The clinical application of this axis needs further in vivo and clinical investigation." @default.
• W3042765400 created "2020-07-23" @default.
• W3042765400 creator A5001800281 @default.
• W3042765400 creator A5003297103 @default.
• W3042765400 creator A5024314954 @default.
• W3042765400 creator A5025754725 @default.
• W3042765400 creator A5034112897 @default.
• W3042765400 creator A5046987682 @default.
• W3042765400 creator A5085399047 @default.
• W3042765400 date "2020-01-01" @default.
• W3042765400 modified "2023-10-06" @default.
• W3042765400 title "Long non-coding RNA KRT16P2/miR-1294/EGFR axis regulates laryngeal squamous cell carcinoma cell aggressiveness." @default.
• W3042765400 cites W105457263 @default.
• W3042765400 cites W1517631474 @default.
• W3042765400 cites W1988617532 @default.
• W3042765400 cites W1991612947 @default.
• W3042765400 cites W1998492748 @default.
• W3042765400 cites W1999439818 @default.
• W3042765400 cites W2007439580 @default.
• W3042765400 cites W2028205153 @default.
• W3042765400 cites W2046387002 @default.
• W3042765400 cites W2066035908 @default.
• W3042765400 cites W2071271349 @default.
• W3042765400 cites W2086968193 @default.
• W3042765400 cites W2087861588 @default.
• W3042765400 cites W2091422774 @default.
• W3042765400 cites W2099795072 @default.
• W3042765400 cites W2113661251 @default.
• W3042765400 cites W2116587853 @default.
• W3042765400 cites W2127627123 @default.
• W3042765400 cites W2130543801 @default.
• W3042765400 cites W2133887344 @default.
• W3042765400 cites W2160968516 @default.
• W3042765400 cites W2166810745 @default.
• W3042765400 cites W2276137469 @default.
• W3042765400 cites W2291638877 @default.
• W3042765400 cites W2513882862 @default.
• W3042765400 cites W2560412269 @default.
• W3042765400 cites W2600635013 @default.
• W3042765400 cites W268846360 @default.
• W3042765400 cites W2747648608 @default.
• W3042765400 cites W2765509240 @default.
• W3042765400 cites W2782056180 @default.
• W3042765400 cites W2783102652 @default.
• W3042765400 cites W2793598720 @default.
• W3042765400 cites W2801763791 @default.
• W3042765400 cites W2804377221 @default.
• W3042765400 cites W2808033675 @default.
• W3042765400 cites W2810108210 @default.
• W3042765400 cites W2810498756 @default.
• W3042765400 cites W2890752591 @default.
• W3042765400 cites W2894511497 @default.
• W3042765400 cites W2898575781 @default.
• W3042765400 cites W2900770680 @default.
• W3042765400 cites W2915075022 @default.
• W3042765400 cites W2966667549 @default.
• W3042765400 cites W2972014039 @default.
• W3042765400 cites W2972828049 @default.
• W3042765400 cites W2974903252 @default.
• W3042765400 cites W3000191286 @default.
• W3042765400 cites W3005527044 @default.
• W3042765400 cites W3021447500 @default.
• W3042765400 cites W3025207716 @default.
• W3042765400 cites W3025630047 @default.
• W3042765400 cites W2793708820 @default.
• W3042765400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7344088" @default.
• W3042765400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32655821" @default.
• W3042765400 hasPublicationYear "2020" @default.
• W3042765400 type Work @default.
• W3042765400 sameAs 3042765400 @default.
• W3042765400 citedByCount "6" @default.
• W3042765400 countsByYear W30427654002020 @default.
• W3042765400 countsByYear W30427654002022 @default.
• W3042765400 countsByYear W30427654002023 @default.
• W3042765400 crossrefType "journal-article" @default.
• W3042765400 hasAuthorship W3042765400A5001800281 @default.
• W3042765400 hasAuthorship W3042765400A5003297103 @default.
• W3042765400 hasAuthorship W3042765400A5024314954 @default.
• W3042765400 hasAuthorship W3042765400A5025754725 @default.
• W3042765400 hasAuthorship W3042765400A5034112897 @default.
• W3042765400 hasAuthorship W3042765400A5046987682 @default.
• W3042765400 hasAuthorship W3042765400A5085399047 @default.
• W3042765400 hasConcept C104317684 @default.
• W3042765400 hasConcept C11960822 @default.
• W3042765400 hasConcept C127561419 @default.
• W3042765400 hasConcept C137738243 @default.
• W3042765400 hasConcept C1491633281 @default.
• W3042765400 hasConcept C173396325 @default.
• W3042765400 hasConcept C502942594 @default.
• W3042765400 hasConcept C54355233 @default.
• W3042765400 hasConcept C55493867 @default.
• W3042765400 hasConcept C62112901 @default.
• W3042765400 hasConcept C62203573 @default.
• W3042765400 hasConcept C71924100 @default.
• W3042765400 hasConcept C75217442 @default.
• W3042765400 hasConcept C81885089 @default.
• W3042765400 hasConcept C86803240 @default.
• W3042765400 hasConcept C95444343 @default.

• next