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• W3042777891 abstract "Aims The cardiorenal syndrome refers to a bidirectional relationship between the kidney and the heart. However, epidemiological evidence of cardiovascular disease (CVD) as a risk factor for chronic kidney disease (CKD) progression is actually scarce. Methods and results We examined the slopes of estimated glomerular filtration rate (eGFR) decline in the 2 years before vs. after an incident hospitalization with heart failure (HF) ( n = 20 420), coronary heart disease (CHD) ( n = 18 152), or stroke ( n = 1808) using data from a complete laboratory data collection in Stockholm, Sweden between 2006 and 2011. eGFR slopes were estimated using mixed‐effect models with unstructured residual correlation. Overall, incident hospitalization with HF and CHD, but not stroke, was significantly associated with a subsequent accelerated decline in eGFR, with a faster eGFR decline and greater slope change after HF than CHD. The pre‐event vs. post‐event eGFR slopes (mL/min/1.73 m 2 per year) were −1.67 (−1.77 to −1.57) vs. −2.76 (−2.82 to −2.71), with a Δslope of −1.09 (−1.16 to −1.02) for HF; −1.09 (−1.20 to −0.98) vs. −1.87 (−1.92 to −1.81), with a Δslope of −0.78 (−0.85 to −0.70) for CHD; and −1.00 (−1.37 to −0.63) vs. −0.99 (−1.19 to −0.78), with a Δslope of 0.02 (−0.24 to 0.27) for stroke. The accelerated declines in eGFR after HF and CHD were consistent across the spectrum of eGFR, although pre‐event eGFR slopes were steeper in lower eGFR (e.g. pre‐event eGFR slope for HF −0.64 (−0.76 to −0.53) for eGFR ≥60 mL/min/1.73 m 2 , −1.43 (−1.57 to −1.30) for eGFR 30–59 mL/min/1.73 m 2 , and −2.42 (−2.71 to −2.12) for eGFR <30 mL/min/1.73 m 2 ). Conclusions Incident hospitalization with cardiac diseases (i.e. HF and CHD) was significantly associated with a subsequent acceleration of eGFR decline." @default.
• W3042777891 created "2020-07-23" @default.
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• W3042777891 date "2020-08-20" @default.
• W3042777891 modified "2023-10-13" @default.
• W3042777891 title "Acceleration of kidney function decline after incident hospitalization with cardiovascular disease: the Stockholm <scp>CREAtinine</scp> Measurements (<scp>SCREAM</scp>) project" @default.
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• W3042777891 doi "https://doi.org/10.1002/ejhf.1968" @default.
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