Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042785591> ?p ?o ?g. }
- W3042785591 endingPage "802" @default.
- W3042785591 startingPage "785" @default.
- W3042785591 abstract "Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder, for which no disease‐modifying therapies are available to date. Although understanding of the precise aetiology of PD is incomplete, it is clear that age, genetic predisposition and environmental stressors increase the risk. At the cellular level, oxidative stress, chronic neuroinflammation, mitochondrial dysfunction and aberrant protein aggregation have been implicated as contributing factors. These detrimental processes are counteracted by elaborate networks of cellular defence mechanisms, one of which is orchestrated by transcription factor nuclear factor‐erythroid 2 p45‐related factor 2 (Nrf2; gene name NFE2L2 ). A wealth of preclinical evidence suggests that Nrf2 activation is beneficial in cellular and animal models of PD. In this review, we summarise the current understanding of mitochondrial dysfunction in PD, the role of Nrf2 in mitochondrial function and explore the potential of Nrf2 as a therapeutic target for mitochondrial dysfunction in PD." @default.
- W3042785591 created "2020-07-23" @default.
- W3042785591 creator A5009288601 @default.
- W3042785591 creator A5053120398 @default.
- W3042785591 date "2020-07-18" @default.
- W3042785591 modified "2023-10-18" @default.
- W3042785591 title "Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease" @default.
- W3042785591 cites W1013361806 @default.
- W3042785591 cites W1433768935 @default.
- W3042785591 cites W1518704304 @default.
- W3042785591 cites W1518890456 @default.
- W3042785591 cites W1561072761 @default.
- W3042785591 cites W1941635000 @default.
- W3042785591 cites W1965285497 @default.
- W3042785591 cites W1967077010 @default.
- W3042785591 cites W1970243208 @default.
- W3042785591 cites W1970687029 @default.
- W3042785591 cites W1971573216 @default.
- W3042785591 cites W1974124666 @default.
- W3042785591 cites W1974898145 @default.
- W3042785591 cites W1975488633 @default.
- W3042785591 cites W1977039417 @default.
- W3042785591 cites W1979458217 @default.
- W3042785591 cites W1982535961 @default.
- W3042785591 cites W1985579354 @default.
- W3042785591 cites W1985917760 @default.
- W3042785591 cites W1986383547 @default.
- W3042785591 cites W1988593777 @default.
- W3042785591 cites W1992681889 @default.
- W3042785591 cites W1995555664 @default.
- W3042785591 cites W2003060043 @default.
- W3042785591 cites W2009745736 @default.
- W3042785591 cites W2012112859 @default.
- W3042785591 cites W2015392958 @default.
- W3042785591 cites W2017275974 @default.
- W3042785591 cites W2019017671 @default.
- W3042785591 cites W2020498032 @default.
- W3042785591 cites W2023598683 @default.
- W3042785591 cites W2024595059 @default.
- W3042785591 cites W2025116212 @default.
- W3042785591 cites W2025286194 @default.
- W3042785591 cites W2026460862 @default.
- W3042785591 cites W2026674234 @default.
- W3042785591 cites W2028904201 @default.
- W3042785591 cites W2030857589 @default.
- W3042785591 cites W2033766052 @default.
- W3042785591 cites W2034087770 @default.
- W3042785591 cites W2035676834 @default.
- W3042785591 cites W2035787181 @default.
- W3042785591 cites W2037202999 @default.
- W3042785591 cites W2038612772 @default.
- W3042785591 cites W2046398127 @default.
- W3042785591 cites W2048496048 @default.
- W3042785591 cites W2050425575 @default.
- W3042785591 cites W2050849483 @default.
- W3042785591 cites W2052790020 @default.
- W3042785591 cites W2052889619 @default.
- W3042785591 cites W2053022803 @default.
- W3042785591 cites W2055285423 @default.
- W3042785591 cites W2056004646 @default.
- W3042785591 cites W2057950283 @default.
- W3042785591 cites W2069581626 @default.
- W3042785591 cites W2069962876 @default.
- W3042785591 cites W2073449985 @default.
- W3042785591 cites W2074813364 @default.
- W3042785591 cites W2074833985 @default.
- W3042785591 cites W2077056816 @default.
- W3042785591 cites W2080716895 @default.
- W3042785591 cites W2080750411 @default.
- W3042785591 cites W2081703555 @default.
- W3042785591 cites W2085478193 @default.
- W3042785591 cites W2091416451 @default.
- W3042785591 cites W2097634036 @default.
- W3042785591 cites W2098303916 @default.
- W3042785591 cites W2100664594 @default.
- W3042785591 cites W2102354517 @default.
- W3042785591 cites W2104409043 @default.
- W3042785591 cites W2105601225 @default.
- W3042785591 cites W2106466768 @default.
- W3042785591 cites W2108326484 @default.
- W3042785591 cites W2110374590 @default.
- W3042785591 cites W2113729748 @default.
- W3042785591 cites W2114806766 @default.
- W3042785591 cites W2118394016 @default.
- W3042785591 cites W2118479885 @default.
- W3042785591 cites W2122341467 @default.
- W3042785591 cites W2124140045 @default.
- W3042785591 cites W2127978123 @default.
- W3042785591 cites W2130497877 @default.
- W3042785591 cites W2131415852 @default.
- W3042785591 cites W2135716022 @default.
- W3042785591 cites W2136388422 @default.
- W3042785591 cites W2139684689 @default.
- W3042785591 cites W2140654974 @default.
- W3042785591 cites W2143906078 @default.
- W3042785591 cites W2147551208 @default.
- W3042785591 cites W2148641246 @default.
- W3042785591 cites W2150656456 @default.