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- W3042810913 abstract "Significance Tuberculosis is a leading cause of death in the world and requires treatment with an arduous multidrug regimen. Many new tuberculosis drugs are in development, and the drug development pipeline would benefit from more rapid methods to learn drug mechanism of action and off-target effects. Here we describe a high-throughput imaging method for rapidly classifying drugs into categories based on the primary and secondary mechanisms of cellular damage caused by different antibacterials called Morphological Evaluation and Understanding of Stress (MorphEUS). We anticipate that MorphEUS will assist in rapidly pinpointing pathway of action of antibacterials for tuberculosis and other bacterial infections." @default.
- W3042810913 created "2020-07-23" @default.
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- W3042810913 date "2020-07-17" @default.
- W3042810913 modified "2023-10-05" @default.
- W3042810913 title "Morphological profiling of tubercle bacilli identifies drug pathways of action" @default.
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- W3042810913 doi "https://doi.org/10.1073/pnas.2002738117" @default.
- W3042810913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7414088" @default.
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