Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042834419> ?p ?o ?g. }
- W3042834419 endingPage "e1008644" @default.
- W3042834419 startingPage "e1008644" @default.
- W3042834419 abstract "The foamy viruses (FV) or spumaviruses are an ancient subfamily of retroviruses that infect a variety of vertebrates. FVs are endemic, but apparently apathogenic, in modern non-human primates. Like other retroviruses, FV replication is inhibited by type-I interferon (IFN). In a previously described screen of IFN-stimulated genes (ISGs), we identified the macaque PHD finger domain protein-11 (PHF11) as an inhibitor of prototype foamy virus (PFV) replication. Here, we show that human and macaque PHF11 inhibit the replication of multiple spumaviruses, but are inactive against several orthoretroviruses. Analysis of other mammalian PHF11 proteins revealed that antiviral activity is host species dependent. Using multiple reporter viruses and cell lines, we determined that PHF11 specifically inhibits a step in the replication cycle that is unique to FVs, namely basal transcription from the FV internal promoter (IP). In so doing, PHF11 prevents expression of the viral transactivator Tas and subsequent activation of the viral LTR promoter. These studies reveal a previously unreported inhibitory mechanism in mammalian cells, that targets a family of ancient viruses and may promote viral latency." @default.
- W3042834419 created "2020-07-23" @default.
- W3042834419 creator A5006143079 @default.
- W3042834419 creator A5052252634 @default.
- W3042834419 creator A5053636210 @default.
- W3042834419 creator A5061038601 @default.
- W3042834419 date "2020-07-17" @default.
- W3042834419 modified "2023-10-17" @default.
- W3042834419 title "Inhibition of spumavirus gene expression by PHF11" @default.
- W3042834419 cites W1532024563 @default.
- W3042834419 cites W1577827703 @default.
- W3042834419 cites W1728530907 @default.
- W3042834419 cites W1865905090 @default.
- W3042834419 cites W1943367649 @default.
- W3042834419 cites W1966547477 @default.
- W3042834419 cites W1972583115 @default.
- W3042834419 cites W1979416107 @default.
- W3042834419 cites W1985707992 @default.
- W3042834419 cites W1986829091 @default.
- W3042834419 cites W1989815073 @default.
- W3042834419 cites W1992473002 @default.
- W3042834419 cites W1999471221 @default.
- W3042834419 cites W2000289003 @default.
- W3042834419 cites W2002569845 @default.
- W3042834419 cites W2004705005 @default.
- W3042834419 cites W2004776082 @default.
- W3042834419 cites W2010462699 @default.
- W3042834419 cites W2011419285 @default.
- W3042834419 cites W2017820115 @default.
- W3042834419 cites W2025859329 @default.
- W3042834419 cites W2031834314 @default.
- W3042834419 cites W2041944666 @default.
- W3042834419 cites W2043344791 @default.
- W3042834419 cites W2046554332 @default.
- W3042834419 cites W2058444131 @default.
- W3042834419 cites W2060557287 @default.
- W3042834419 cites W2060605945 @default.
- W3042834419 cites W2062025398 @default.
- W3042834419 cites W2067341270 @default.
- W3042834419 cites W2078406153 @default.
- W3042834419 cites W2079664946 @default.
- W3042834419 cites W2088057616 @default.
- W3042834419 cites W2097735738 @default.
- W3042834419 cites W2106872247 @default.
- W3042834419 cites W2108894254 @default.
- W3042834419 cites W2112342170 @default.
- W3042834419 cites W2113203969 @default.
- W3042834419 cites W2114151755 @default.
- W3042834419 cites W2114655112 @default.
- W3042834419 cites W2120463956 @default.
- W3042834419 cites W2121652210 @default.
- W3042834419 cites W2134342659 @default.
- W3042834419 cites W2134813931 @default.
- W3042834419 cites W2137478413 @default.
- W3042834419 cites W2138443348 @default.
- W3042834419 cites W2139376543 @default.
- W3042834419 cites W2143829480 @default.
- W3042834419 cites W2147153603 @default.
- W3042834419 cites W2152349049 @default.
- W3042834419 cites W2157226092 @default.
- W3042834419 cites W2158330182 @default.
- W3042834419 cites W2159611842 @default.
- W3042834419 cites W2162183294 @default.
- W3042834419 cites W2169311326 @default.
- W3042834419 cites W2170725518 @default.
- W3042834419 cites W2407616149 @default.
- W3042834419 cites W2519084386 @default.
- W3042834419 cites W2580087452 @default.
- W3042834419 cites W2756541019 @default.
- W3042834419 doi "https://doi.org/10.1371/journal.ppat.1008644" @default.
- W3042834419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7390438" @default.
- W3042834419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32678836" @default.
- W3042834419 hasPublicationYear "2020" @default.
- W3042834419 type Work @default.
- W3042834419 sameAs 3042834419 @default.
- W3042834419 citedByCount "10" @default.
- W3042834419 countsByYear W30428344192021 @default.
- W3042834419 countsByYear W30428344192022 @default.
- W3042834419 countsByYear W30428344192023 @default.
- W3042834419 crossrefType "journal-article" @default.
- W3042834419 hasAuthorship W3042834419A5006143079 @default.
- W3042834419 hasAuthorship W3042834419A5052252634 @default.
- W3042834419 hasAuthorship W3042834419A5053636210 @default.
- W3042834419 hasAuthorship W3042834419A5061038601 @default.
- W3042834419 hasBestOaLocation W30428344191 @default.
- W3042834419 hasConcept C104317684 @default.
- W3042834419 hasConcept C1292079 @default.
- W3042834419 hasConcept C138885662 @default.
- W3042834419 hasConcept C140704245 @default.
- W3042834419 hasConcept C150194340 @default.
- W3042834419 hasConcept C159047783 @default.
- W3042834419 hasConcept C179926584 @default.
- W3042834419 hasConcept C2522874641 @default.
- W3042834419 hasConcept C2776178377 @default.
- W3042834419 hasConcept C41895202 @default.
- W3042834419 hasConcept C54355233 @default.
- W3042834419 hasConcept C86803240 @default.
- W3042834419 hasConcept C95444343 @default.