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- W3042855887 abstract "Abstract T-bet is the lineage-specifying transcription factor for CD4 + T helper type 1 (T H 1) cells. T-bet has also been found in other CD4 + T cell subsets, including T H 17 cells and T REG , where it modulates their functional characteristics. However, we lack information on when and where T-bet is expressed during T cell differentiation and how this impacts T cell function. To address this, we traced the ontogeny of T-bet-expressing cells using a fluorescent fate-mapping mouse line. We demonstrate that T-bet is expressed in a subset of CD4 + T cells with naïve cell surface markers and that this novel cell population is phenotypically and functionally distinct from conventional naïve CD4 + T cells. These cells are also distinct from previously described populations of memory phenotype and stem cell-like T cells. Naïve-like T-bet-experienced cells are polarised to the T H 1 lineage, predisposed to produce IFNγ upon cell activation, and resist repolarisation to other lineages in vitro and in vivo . These results demonstrate that lineage-specifying factors can function to polarise T cells in the absence of canonical markers of T cell activation and that this has an impact on the subsequent T helper response." @default.
- W3042855887 created "2020-07-23" @default.
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- W3042855887 date "2020-07-14" @default.
- W3042855887 modified "2023-09-27" @default.
- W3042855887 title "A population of CD4+ T cells with a naïve phenotype stably polarized to the TH1 lineage" @default.
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- W3042855887 doi "https://doi.org/10.1101/2020.07.14.202168" @default.
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