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- W3042865514 abstract "Many drug molecules that are currently in the market suffer from short half-life, poor absorption, low specificity, rapid degradation, and resistance development. The design and development of lipophilic prodrugs can provide numerous benefits to overcome these challenges. Fatty acids (FAs), which are lipophilic biomolecules constituted of essential components of the living cells, carry out many necessary functions required for the development of efficient prodrugs. Chemical conjugation of FAs to drug molecules may change their pharmacodynamics/pharmacokinetics in vivo and even their toxicity profile. Well–designed FA-based prodrugs can also present other benefits, such as improved oral bioavailability, promoted tumor targeting efficiency, controlled drug release, and enhanced cellular penetration, leading to improved therapeutic efficacy. In this review, we discuss diverse drug molecules conjugated to various unsaturated FAs. Furthermore, various drug-FA conjugates loaded into various nanostructure delivery systems, including liposomes, solid lipid nanoparticles, emulsions, nano-assemblies, micelles, and polymeric nanoparticles, are reviewed. The present review aims to inspire readers to explore new avenues in prodrug design based on the various FAs with or without nanostructured delivery systems. Graphical Abstract • Fatty acid is a promising platform in the development of various prodrugs. • Fatty acid-based prodrugs can improve biological properties of parent drugs. • Ester and amide bonds are the most commonly used bonds to form fatty acid-drug conjugates. • Fatty acid-based prodrugs can generate nano-DDSs with higher loading capacity." @default.
- W3042865514 created "2020-07-23" @default.
- W3042865514 creator A5007531597 @default.
- W3042865514 creator A5018692378 @default.
- W3042865514 creator A5032252177 @default.
- W3042865514 creator A5058005723 @default.
- W3042865514 creator A5058490350 @default.
- W3042865514 creator A5071356523 @default.
- W3042865514 date "2020-10-01" @default.
- W3042865514 modified "2023-10-05" @default.
- W3042865514 title "Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel nanomedicines" @default.
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