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- W3042866976 abstract "Abstract Objective Gabapentin (GBP) and pregabalin (PGB) have been used to treat alcohol use disorder (AUD) and alcohol withdrawal, but with inconsistent results. In this meta‐analysis, we explored the effects of GBP/PGB treatment on AUD and their effects on withdrawal, craving, depression, and sleep disturbance in AUD patients. Methods We carried out a systematic review and meta‐analysis of randomized controlled trials comparing the effects of GBP/PGB on AUD with those of a placebo or control treatment. Electronic databases were searched for relevant articles published before September 2019. The primary outcome was defined as the efficacy measure on achieving abstinence or reducing alcohol consumption in a hierarchical order. We included 16 studies in our meta‐analysis. Results Overall, GBP had no significant benefit comparing to placebo or control treatment (Hedges' g = 0.0725, p = 0.6743). For specific alcohol‐related outcome, GBP had significant effect on percentage of heavy drink (Hedges' g = 0.5478, p = 0.0441) and alcohol withdrawal symptoms (Hedges' g = 0.2475, p = 0.0425). GBP/PGB did not have significant beneficial effect on craving, depressive symptoms, or sleep disturbance. Instability was shown in sensitivity analyses of some above results. Conclusions GBP may be helpful to reduce AUD patients' heavy drinking behavior and withdrawal, but more studies are needed for drawing conclusions." @default.
- W3042866976 created "2020-07-23" @default.
- W3042866976 creator A5000269154 @default.
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- W3042866976 date "2020-07-15" @default.
- W3042866976 modified "2023-09-26" @default.
- W3042866976 title "Gabapentinoids for treatment of alcohol use disorder: A systematic review and meta‐analysis" @default.
- W3042866976 cites W1537972189 @default.
- W3042866976 cites W1910982087 @default.
- W3042866976 cites W1912196550 @default.
- W3042866976 cites W1918420015 @default.
- W3042866976 cites W1924646378 @default.
- W3042866976 cites W1960053172 @default.
- W3042866976 cites W1965829294 @default.
- W3042866976 cites W1978434699 @default.
- W3042866976 cites W1981941375 @default.
- W3042866976 cites W1984472726 @default.
- W3042866976 cites W1988098024 @default.
- W3042866976 cites W1995753351 @default.
- W3042866976 cites W2005781055 @default.
- W3042866976 cites W2009513529 @default.
- W3042866976 cites W2013138962 @default.
- W3042866976 cites W2013203029 @default.
- W3042866976 cites W2021222157 @default.
- W3042866976 cites W2037311654 @default.
- W3042866976 cites W2050505630 @default.
- W3042866976 cites W2056593134 @default.
- W3042866976 cites W2057212295 @default.
- W3042866976 cites W2060713002 @default.
- W3042866976 cites W2061159066 @default.
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- W3042866976 cites W2075663070 @default.
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- W3042866976 cites W2086090870 @default.
- W3042866976 cites W2089272715 @default.
- W3042866976 cites W2089724708 @default.
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- W3042866976 cites W2794205818 @default.
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- W3042866976 doi "https://doi.org/10.1002/hup.2751" @default.
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