FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042873092> ?p ?o ?g. }

• W3042873092 endingPage "5039" @default.
• W3042873092 startingPage "5023" @default.
• W3042873092 abstract "Patients with posttraumatic stress disorder (PTSD) appear to manifest two opposing tendencies in their attentional biases and symptoms. However, whether common neural mechanisms account for their opposing attentional biases and symptoms remains unknown. We here propose a model in which reciprocal inhibition between the amygdala and ventromedial prefrontal cortex (vmPFC) predicts synchronized alternations between emotional under- and overmodulatory states at the neural, behavioral, and symptom levels within the same patients. This reciprocal inhibition model predicts that when the amygdala is dominant, patients enter an emotional undermodulatory state where they show attentional bias toward threat and manifest re-experiencing symptoms. In contrast, when the vmPFC is dominant, patients are predicted to enter an emotional overmodulatory state where they show attentional bias away from threat and avoidance symptoms. To test the model, we performed a behavioral meta-analysis (total N = 491), analyses of own behavioral study (N = 20), and a neuroimaging meta-analysis (total N = 316). Supporting the model, we found the distributions of behavioral attentional measurements to be bimodal, suggesting alternations between the states within patients. Moreover, attentional bias toward threat was related to re-experiencing symptoms, whereas attentional bias away from threat was related with avoidance symptoms. We also found that the increase and decrease of activity in the left amygdala activity was related with re-experiencing and avoidance symptoms, respectively. Our model may help elucidate the neural mechanisms differentiating nondissociative and dissociative subtypes of PTSD, which usually show differential emotional modulatory levels. It may thus provide a new venue for therapies targeting each subtype." @default.
• W3042873092 created "2020-07-23" @default.
• W3042873092 creator A5000664738 @default.
• W3042873092 creator A5005581859 @default.
• W3042873092 creator A5013182955 @default.
• W3042873092 creator A5017836960 @default.
• W3042873092 creator A5017868441 @default.
• W3042873092 creator A5020912488 @default.
• W3042873092 creator A5028840283 @default.
• W3042873092 creator A5029544518 @default.
• W3042873092 creator A5034723746 @default.
• W3042873092 creator A5058044413 @default.
• W3042873092 creator A5059145126 @default.
• W3042873092 creator A5069223833 @default.
• W3042873092 creator A5071368896 @default.
• W3042873092 creator A5085122354 @default.
• W3042873092 creator A5089755600 @default.
• W3042873092 date "2020-07-20" @default.
• W3042873092 modified "2023-10-14" @default.
• W3042873092 title "A reciprocal inhibition model of alternations between under-/overemotional modulatory states in patients with PTSD" @default.
• W3042873092 cites W1015756911 @default.
• W3042873092 cites W1532970882 @default.
• W3042873092 cites W1846016529 @default.
• W3042873092 cites W1901259421 @default.
• W3042873092 cites W1903968024 @default.
• W3042873092 cites W1910429665 @default.
• W3042873092 cites W1937799384 @default.
• W3042873092 cites W1964647061 @default.
• W3042873092 cites W1966806791 @default.
• W3042873092 cites W1977502547 @default.
• W3042873092 cites W1985155058 @default.
• W3042873092 cites W1989045560 @default.
• W3042873092 cites W1989756802 @default.
• W3042873092 cites W1990397347 @default.
• W3042873092 cites W2000843844 @default.
• W3042873092 cites W2002801119 @default.
• W3042873092 cites W2003006852 @default.
• W3042873092 cites W2003598308 @default.
• W3042873092 cites W2015982946 @default.
• W3042873092 cites W2017108196 @default.
• W3042873092 cites W2040185749 @default.
• W3042873092 cites W2042479971 @default.
• W3042873092 cites W2044592212 @default.
• W3042873092 cites W2049812132 @default.
• W3042873092 cites W2055766556 @default.
• W3042873092 cites W2056433817 @default.
• W3042873092 cites W2064896421 @default.
• W3042873092 cites W2074911271 @default.
• W3042873092 cites W2080641591 @default.
• W3042873092 cites W2081999660 @default.
• W3042873092 cites W2084994381 @default.
• W3042873092 cites W2086354265 @default.
• W3042873092 cites W2092796129 @default.
• W3042873092 cites W2101424636 @default.
• W3042873092 cites W2102887327 @default.
• W3042873092 cites W2103881507 @default.
• W3042873092 cites W2104622135 @default.
• W3042873092 cites W2106057704 @default.
• W3042873092 cites W2106089606 @default.
• W3042873092 cites W2108888119 @default.
• W3042873092 cites W2109405095 @default.
• W3042873092 cites W2117925162 @default.
• W3042873092 cites W2122107405 @default.
• W3042873092 cites W2124556602 @default.
• W3042873092 cites W2128044703 @default.
• W3042873092 cites W2133036344 @default.
• W3042873092 cites W2146256171 @default.
• W3042873092 cites W2149608940 @default.
• W3042873092 cites W2151437219 @default.
• W3042873092 cites W2155460100 @default.
• W3042873092 cites W2158107158 @default.
• W3042873092 cites W2164285273 @default.
• W3042873092 cites W2166864184 @default.
• W3042873092 cites W2168664484 @default.
• W3042873092 cites W2206738142 @default.
• W3042873092 cites W2321066001 @default.
• W3042873092 cites W2321542948 @default.
• W3042873092 cites W2439643207 @default.
• W3042873092 cites W2472694591 @default.
• W3042873092 cites W2595960708 @default.
• W3042873092 cites W2739325771 @default.
• W3042873092 cites W2746747038 @default.
• W3042873092 cites W2765862284 @default.
• W3042873092 cites W2884319195 @default.
• W3042873092 cites W2887468515 @default.
• W3042873092 cites W2896766486 @default.
• W3042873092 cites W2906136034 @default.
• W3042873092 cites W2921355666 @default.
• W3042873092 cites W4211189621 @default.
• W3042873092 cites W4213010815 @default.
• W3042873092 cites W4247665917 @default.
• W3042873092 cites W4294214781 @default.
• W3042873092 cites W904764605 @default.
• W3042873092 doi "https://doi.org/10.1038/s41380-020-0827-0" @default.
• W3042873092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8589665" @default.
• W3042873092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32684635" @default.
• W3042873092 hasPublicationYear "2020" @default.
• W3042873092 type Work @default.

• next