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• W3042906013 abstract "Significance Feedback control of cholesterol metabolism is essential for cell viability and prevention of heart attacks. Cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein, which delivers cholesterol to lysosomes. To exert feedback control, cholesterol must reach the endoplasmic reticulum (ER). Here we use a CRISPR screen to show that lysosome-derived cholesterol moves first to the plasma membrane and then to the ER. The last movement requires an enzyme that produces phosphatidylserine. This demonstrates that transmembrane movement of one lipid (cholesterol) requires another lipid (phosphatidylserine). Our results explain how one organelle (ER) monitors the cholesterol content of another organelle (plasma membrane), thereby maintaining membrane integrity and ensuring cell survival." @default.
• W3042906013 created "2020-07-23" @default.
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• W3042906013 date "2020-07-20" @default.
• W3042906013 modified "2023-10-10" @default.
• W3042906013 title "Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine" @default.
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• W3042906013 doi "https://doi.org/10.1073/pnas.2010682117" @default.
• W3042906013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7414171" @default.
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• W3042906013 hasPublicationYear "2020" @default.
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