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• W3042907380 abstract "Several studies have underlined the interplay among host-microbiome and pathophysiological conditions of animals. Research has also focused specifically on whether and how changes in the gut microbiome have provoked the occurrence of pathological phenomena affecting cartilage and joints in humans and in laboratory animals. Here, we tried to evaluate the relationship between the gut microbiome and the hip and elbow arthritis in owned dogs. The study included 14 dogs suffering from chronic arthritis (AD) and 13 healthy dogs (HD). After the first visit and during the period of the study, the dogs, under the supervision of the owner, were fed a semi-moist complete diet supplemented with omega 3 fatty acids. Feces and blood samples were collected in the clinic at the first visit (T0) and after days (T45). The plasma C-reactive protein (CRP) was higher, and the serum vitamin B12 and folate concentrations were lower (p < 0.05) in the AD group in comparison to the HD group. Data of the fecal microbiome showed that the relative abundances of the genus Megamonas were higher in AD (p < 0.001), while the relative abundance of the families Paraprevotellaceae, Porphyromonadaceae, and Mogibacteriaceae was significantly lower in comparison to HD. The results of the study identified several bacterial groups that differed significantly in the fecal microbiome between healthy and diseased dogs. If the observed differences in fecal bacterial composition predispose dogs to hip and elbow arthritis or if these differences reflect a correlation with these conditions deserves further investigation." @default.
• W3042907380 created "2020-07-23" @default.
• W3042907380 creator A5001766586 @default.
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• W3042907380 creator A5031001206 @default.
• W3042907380 date "2020-07-14" @default.
• W3042907380 modified "2023-09-30" @default.
• W3042907380 title "Gut Microbiome of Healthy and Arthritic Dogs" @default.
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• W3042907380 doi "https://doi.org/10.3390/vetsci7030092" @default.
• W3042907380 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7558702" @default.
• W3042907380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32674496" @default.
• W3042907380 hasPublicationYear "2020" @default.
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