FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042967706> ?p ?o ?g. }

• W3042967706 endingPage "100107" @default.
• W3042967706 startingPage "100107" @default.
• W3042967706 abstract "Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning of the patients. Underlying pathological mechanisms are to a large extent unknown, but the presence of autoantibodies, cytokine pattern deviations and the presentation of cognitive and autonomic nervous system related symptoms provide evidence for ME being an immunological disorder with elements of autoimmunity. Increased levels of autoantibodies binding to adrenergic and muscarinic receptors in ME-patients have been reported. It is hypothesized that these autoantibodies have pathological significance and contribute to the ME-specific symptoms, however, these observations need to be validated. This study was designed to investigate potential differences in adrenergic and muscarinic receptor autoantibody levels in plasma and cerebrospinal fluid (CSF) samples between ME patients and gender and age-matched healthy controls, and to correlate the autoantibody levels to disease severity. We collected bodyfluids and health-related questionnaires from two Swedish ME cohorts, plasma and CSF from one of the cohorts (n ​= ​24), only plasma from the second cohort (n ​= ​24) together with plasma samples (n ​= ​24) and CSF (n ​= ​6) from healthy controls. All samples were analysed for IgG autoantibodies directed against Alpha- (α1, α2) and Beta- (β1-3) adrenergic receptors and Muscarinic (M) 1–5 acetylcholine receptors using an ELISA technique. The questionnaires were used as measures of disease severity. Significant increases in autoantibody levels in ME patients compared to controls were found for M3 and M4 -receptors in both cohorts and β1, β2, M3 and M4-receptors in one cohort. No significant correlations were found between autoantibody levels and disease severity. No significant levels of autoantibodies were detected in the CSF samples. These findings support previous findings that there exists a general pattern of increased antibody levels to adrenergic and muscarinic receptors within the ME patient group. However, the role of increased adrenergic and muscarinic receptor autoantibodies in the pathogenesis of ME is still uncertain and further research is needed to evaluate the clinical significance of these findings." @default.
• W3042967706 created "2020-07-23" @default.
• W3042967706 creator A5003331451 @default.
• W3042967706 creator A5035190100 @default.
• W3042967706 creator A5041671628 @default.
• W3042967706 creator A5073531021 @default.
• W3042967706 creator A5089758540 @default.
• W3042967706 creator A5089780292 @default.
• W3042967706 date "2020-08-01" @default.
• W3042967706 modified "2023-10-16" @default.
• W3042967706 title "Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts" @default.
• W3042967706 cites W1595840462 @default.
• W3042967706 cites W1810509997 @default.
• W3042967706 cites W1969027187 @default.
• W3042967706 cites W2098287790 @default.
• W3042967706 cites W2110371849 @default.
• W3042967706 cites W2113872014 @default.
• W3042967706 cites W2116310706 @default.
• W3042967706 cites W2118023524 @default.
• W3042967706 cites W2155596333 @default.
• W3042967706 cites W2167270466 @default.
• W3042967706 cites W2296125912 @default.
• W3042967706 cites W2346117701 @default.
• W3042967706 cites W2550334822 @default.
• W3042967706 cites W2606042790 @default.
• W3042967706 cites W2737787032 @default.
• W3042967706 cites W2792774541 @default.
• W3042967706 cites W2795591851 @default.
• W3042967706 cites W2902679943 @default.
• W3042967706 cites W2986148736 @default.
• W3042967706 doi "https://doi.org/10.1016/j.bbih.2020.100107" @default.
• W3042967706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8474431" @default.
• W3042967706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34589868" @default.
• W3042967706 hasPublicationYear "2020" @default.
• W3042967706 type Work @default.
• W3042967706 sameAs 3042967706 @default.
• W3042967706 citedByCount "20" @default.
• W3042967706 countsByYear W30429677062021 @default.
• W3042967706 countsByYear W30429677062022 @default.
• W3042967706 countsByYear W30429677062023 @default.
• W3042967706 crossrefType "journal-article" @default.
• W3042967706 hasAuthorship W3042967706A5003331451 @default.
• W3042967706 hasAuthorship W3042967706A5035190100 @default.
• W3042967706 hasAuthorship W3042967706A5041671628 @default.
• W3042967706 hasAuthorship W3042967706A5073531021 @default.
• W3042967706 hasAuthorship W3042967706A5089758540 @default.
• W3042967706 hasAuthorship W3042967706A5089780292 @default.
• W3042967706 hasBestOaLocation W30429677061 @default.
• W3042967706 hasConcept C126322002 @default.
• W3042967706 hasConcept C134018914 @default.
• W3042967706 hasConcept C159654299 @default.
• W3042967706 hasConcept C163764329 @default.
• W3042967706 hasConcept C170493617 @default.
• W3042967706 hasConcept C203014093 @default.
• W3042967706 hasConcept C207886595 @default.
• W3042967706 hasConcept C2777899865 @default.
• W3042967706 hasConcept C2779134260 @default.
• W3042967706 hasConcept C2780130043 @default.
• W3042967706 hasConcept C33789571 @default.
• W3042967706 hasConcept C529278444 @default.
• W3042967706 hasConcept C71924100 @default.
• W3042967706 hasConceptScore W3042967706C126322002 @default.
• W3042967706 hasConceptScore W3042967706C134018914 @default.
• W3042967706 hasConceptScore W3042967706C159654299 @default.
• W3042967706 hasConceptScore W3042967706C163764329 @default.
• W3042967706 hasConceptScore W3042967706C170493617 @default.
• W3042967706 hasConceptScore W3042967706C203014093 @default.
• W3042967706 hasConceptScore W3042967706C207886595 @default.
• W3042967706 hasConceptScore W3042967706C2777899865 @default.
• W3042967706 hasConceptScore W3042967706C2779134260 @default.
• W3042967706 hasConceptScore W3042967706C2780130043 @default.
• W3042967706 hasConceptScore W3042967706C33789571 @default.
• W3042967706 hasConceptScore W3042967706C529278444 @default.
• W3042967706 hasConceptScore W3042967706C71924100 @default.
• W3042967706 hasFunder F4320314888 @default.
• W3042967706 hasLocation W30429677061 @default.
• W3042967706 hasLocation W30429677062 @default.
• W3042967706 hasLocation W30429677063 @default.
• W3042967706 hasLocation W30429677064 @default.
• W3042967706 hasOpenAccess W3042967706 @default.
• W3042967706 hasPrimaryLocation W30429677061 @default.
• W3042967706 hasRelatedWork W1970289512 @default.
• W3042967706 hasRelatedWork W2018368842 @default.
• W3042967706 hasRelatedWork W2033472167 @default.
• W3042967706 hasRelatedWork W2034583712 @default.
• W3042967706 hasRelatedWork W2050559793 @default.
• W3042967706 hasRelatedWork W2063619316 @default.
• W3042967706 hasRelatedWork W2094064741 @default.
• W3042967706 hasRelatedWork W2160953928 @default.
• W3042967706 hasRelatedWork W2169225653 @default.
• W3042967706 hasRelatedWork W2414846389 @default.
• W3042967706 hasVolume "7" @default.
• W3042967706 isParatext "false" @default.
• W3042967706 isRetracted "false" @default.
• W3042967706 magId "3042967706" @default.
• W3042967706 workType "article" @default.