Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043001617> ?p ?o ?g. }
- W3043001617 endingPage "627" @default.
- W3043001617 startingPage "627" @default.
- W3043001617 abstract "Increased formation of advanced glycation end products (AGEs) plays an important role in the development of diabetic retinopathy (DR) via blood-retinal barrier (BRB) dysfunction, and reduction of AGEs has been suggested as a therapeutic target for DR. In this study, we examined whether CPA4-1, a herbal combination of Cinnamomi Ramulus and Paeoniae Radix, inhibits AGE formation. CPA4-1 and fenofibrate were tested to ameliorate changes in retinal capillaries and retinal occludin expression in db/db mice, a mouse model of obesity-induced type 2 diabetes. CPA4-1 (100 mg/kg) or fenofibrate (100 mg/kg) were orally administered once a day for 12 weeks. CPA4-1 (the half maximal inhibitory concentration, IC50 = 6.84 ± 0.08 μg/mL) showed approximately 11.44-fold higher inhibitory effect on AGE formation than that of aminoguanidine (AG, the inhibitor of AGEs, IC50 = 78.28 ± 4.24 μg/mL), as well as breaking effect on AGE-bovine serum albumin crosslinking with collagen (IC50 = 1.30 ± 0.37 μg/mL). CPA4-1 treatment ameliorated BRB leakage and tended to increase retinal occludin expression in db/db mice. CPA4-1 or fenofibrate treatment significantly reduced retinal acellular capillary formation in db/db mice. These findings suggested the potential of CPA4-1 as a therapeutic supplement for protection against retinal vascular permeability diseases." @default.
- W3043001617 created "2020-07-23" @default.
- W3043001617 creator A5009660847 @default.
- W3043001617 creator A5020282158 @default.
- W3043001617 creator A5022145997 @default.
- W3043001617 creator A5039187145 @default.
- W3043001617 creator A5061737220 @default.
- W3043001617 creator A5079152218 @default.
- W3043001617 creator A5087371439 @default.
- W3043001617 creator A5087810531 @default.
- W3043001617 date "2020-07-16" @default.
- W3043001617 modified "2023-09-24" @default.
- W3043001617 title "The Herbal Combination CPA4-1 Inhibits Changes in Retinal Capillaries and Reduction of Retinal Occludin in db/db Mice" @default.
- W3043001617 cites W1922654183 @default.
- W3043001617 cites W1967729975 @default.
- W3043001617 cites W1978730983 @default.
- W3043001617 cites W2000478369 @default.
- W3043001617 cites W2018511776 @default.
- W3043001617 cites W2022231516 @default.
- W3043001617 cites W2025648627 @default.
- W3043001617 cites W2032576836 @default.
- W3043001617 cites W2036022419 @default.
- W3043001617 cites W2037585898 @default.
- W3043001617 cites W2062199187 @default.
- W3043001617 cites W2076093871 @default.
- W3043001617 cites W2087122397 @default.
- W3043001617 cites W2094296585 @default.
- W3043001617 cites W2103831817 @default.
- W3043001617 cites W2115337518 @default.
- W3043001617 cites W2120833123 @default.
- W3043001617 cites W2137489898 @default.
- W3043001617 cites W2146161717 @default.
- W3043001617 cites W2151791399 @default.
- W3043001617 cites W2169265493 @default.
- W3043001617 cites W2245434279 @default.
- W3043001617 cites W2254164156 @default.
- W3043001617 cites W2255840627 @default.
- W3043001617 cites W2407631773 @default.
- W3043001617 cites W2416244166 @default.
- W3043001617 cites W2464706698 @default.
- W3043001617 cites W2523464349 @default.
- W3043001617 cites W2560267311 @default.
- W3043001617 cites W2590456214 @default.
- W3043001617 cites W2710409284 @default.
- W3043001617 cites W2736032980 @default.
- W3043001617 cites W2750958340 @default.
- W3043001617 cites W2768469548 @default.
- W3043001617 cites W2771645581 @default.
- W3043001617 cites W2883721086 @default.
- W3043001617 cites W3033052083 @default.
- W3043001617 doi "https://doi.org/10.3390/antiox9070627" @default.
- W3043001617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7402168" @default.
- W3043001617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32708791" @default.
- W3043001617 hasPublicationYear "2020" @default.
- W3043001617 type Work @default.
- W3043001617 sameAs 3043001617 @default.
- W3043001617 citedByCount "2" @default.
- W3043001617 countsByYear W30430016172020 @default.
- W3043001617 countsByYear W30430016172021 @default.
- W3043001617 crossrefType "journal-article" @default.
- W3043001617 hasAuthorship W3043001617A5009660847 @default.
- W3043001617 hasAuthorship W3043001617A5020282158 @default.
- W3043001617 hasAuthorship W3043001617A5022145997 @default.
- W3043001617 hasAuthorship W3043001617A5039187145 @default.
- W3043001617 hasAuthorship W3043001617A5061737220 @default.
- W3043001617 hasAuthorship W3043001617A5079152218 @default.
- W3043001617 hasAuthorship W3043001617A5087371439 @default.
- W3043001617 hasAuthorship W3043001617A5087810531 @default.
- W3043001617 hasBestOaLocation W30430016171 @default.
- W3043001617 hasConcept C113045295 @default.
- W3043001617 hasConcept C118487528 @default.
- W3043001617 hasConcept C126322002 @default.
- W3043001617 hasConcept C134018914 @default.
- W3043001617 hasConcept C147990577 @default.
- W3043001617 hasConcept C177779419 @default.
- W3043001617 hasConcept C185592680 @default.
- W3043001617 hasConcept C2775962179 @default.
- W3043001617 hasConcept C2778110834 @default.
- W3043001617 hasConcept C2778371105 @default.
- W3043001617 hasConcept C2779829184 @default.
- W3043001617 hasConcept C2780827179 @default.
- W3043001617 hasConcept C55493867 @default.
- W3043001617 hasConcept C555293320 @default.
- W3043001617 hasConcept C71924100 @default.
- W3043001617 hasConcept C98274493 @default.
- W3043001617 hasConceptScore W3043001617C113045295 @default.
- W3043001617 hasConceptScore W3043001617C118487528 @default.
- W3043001617 hasConceptScore W3043001617C126322002 @default.
- W3043001617 hasConceptScore W3043001617C134018914 @default.
- W3043001617 hasConceptScore W3043001617C147990577 @default.
- W3043001617 hasConceptScore W3043001617C177779419 @default.
- W3043001617 hasConceptScore W3043001617C185592680 @default.
- W3043001617 hasConceptScore W3043001617C2775962179 @default.
- W3043001617 hasConceptScore W3043001617C2778110834 @default.
- W3043001617 hasConceptScore W3043001617C2778371105 @default.
- W3043001617 hasConceptScore W3043001617C2779829184 @default.
- W3043001617 hasConceptScore W3043001617C2780827179 @default.
- W3043001617 hasConceptScore W3043001617C55493867 @default.