Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043001684> ?p ?o ?g. }
- W3043001684 abstract "Abstract Significant efforts have been made to ameliorate diabetic nephropathy (DN) by inhibiting protein kinase C. However, these efforts have not been successful in human trials, suggesting that novel therapeutic strategies are required. Thus far, it has been reported that green tea polyphenol epigallocatechin gallate (EGCg) improved albuminuria in DN in a human trial. Our previous study revealed that activation of diacylglycerol kinase α (DGKα) plays a crucial role in the amelioration of DN and that EGCg activates DGKα. Here, we investigated whether and how DGKα contributes to the amelioration of DN upon stimulation by EGCg by using streptozotocin-induced type 1 diabetic model mice. Our results revealed that EGCg ameliorated albuminuria in DN through DGKα in vivo, and methylated EGCg, which has higher absorption in the plasma improved albuminuria in DN effectively. Additionally, we showed that c-Src mediated EGCg-induced DGKα translocation and colocalized with the 67 kDa laminin receptor, which is an EGCg receptor. Furthermore, EGCg attenuated the loss of podocytes in DN by preventing a decrease in focal adhesion under high glucose conditions. Our results indicate that the DGKα pathway is an attractive therapeutic target and that activating this pathway is a novel strategy for treating DN." @default.
- W3043001684 created "2020-07-23" @default.
- W3043001684 creator A5016477472 @default.
- W3043001684 creator A5036922052 @default.
- W3043001684 creator A5043637238 @default.
- W3043001684 creator A5047203788 @default.
- W3043001684 creator A5071690920 @default.
- W3043001684 creator A5077816114 @default.
- W3043001684 date "2020-07-16" @default.
- W3043001684 modified "2023-10-17" @default.
- W3043001684 title "The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase α" @default.
- W3043001684 cites W1488975603 @default.
- W3043001684 cites W1927620573 @default.
- W3043001684 cites W1967172766 @default.
- W3043001684 cites W1967853257 @default.
- W3043001684 cites W1971316445 @default.
- W3043001684 cites W1971517880 @default.
- W3043001684 cites W1975768992 @default.
- W3043001684 cites W1985821454 @default.
- W3043001684 cites W1987889022 @default.
- W3043001684 cites W1989476960 @default.
- W3043001684 cites W1994696115 @default.
- W3043001684 cites W1995179192 @default.
- W3043001684 cites W2010124690 @default.
- W3043001684 cites W2011619590 @default.
- W3043001684 cites W2020004862 @default.
- W3043001684 cites W2033998197 @default.
- W3043001684 cites W2036410761 @default.
- W3043001684 cites W2040380855 @default.
- W3043001684 cites W2046561530 @default.
- W3043001684 cites W2049471272 @default.
- W3043001684 cites W2052818515 @default.
- W3043001684 cites W2055168506 @default.
- W3043001684 cites W2063287373 @default.
- W3043001684 cites W2064064050 @default.
- W3043001684 cites W2064601258 @default.
- W3043001684 cites W2068112852 @default.
- W3043001684 cites W2073544224 @default.
- W3043001684 cites W2079269324 @default.
- W3043001684 cites W2079724447 @default.
- W3043001684 cites W2084060247 @default.
- W3043001684 cites W2084514806 @default.
- W3043001684 cites W2084823433 @default.
- W3043001684 cites W2101417448 @default.
- W3043001684 cites W2107545273 @default.
- W3043001684 cites W2110043908 @default.
- W3043001684 cites W2134773861 @default.
- W3043001684 cites W2135785702 @default.
- W3043001684 cites W2136490577 @default.
- W3043001684 cites W2143322860 @default.
- W3043001684 cites W2143787351 @default.
- W3043001684 cites W2154111720 @default.
- W3043001684 cites W2158240118 @default.
- W3043001684 cites W2161624379 @default.
- W3043001684 cites W2161793406 @default.
- W3043001684 cites W2165325650 @default.
- W3043001684 cites W2168450345 @default.
- W3043001684 cites W2279887543 @default.
- W3043001684 cites W2549976854 @default.
- W3043001684 cites W2565348728 @default.
- W3043001684 cites W2617784703 @default.
- W3043001684 cites W2782004981 @default.
- W3043001684 cites W2903631224 @default.
- W3043001684 cites W4249404457 @default.
- W3043001684 cites W2136279357 @default.
- W3043001684 doi "https://doi.org/10.1038/s41598-020-68716-6" @default.
- W3043001684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7366667" @default.
- W3043001684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32678222" @default.
- W3043001684 hasPublicationYear "2020" @default.
- W3043001684 type Work @default.
- W3043001684 sameAs 3043001684 @default.
- W3043001684 citedByCount "17" @default.
- W3043001684 countsByYear W30430016842021 @default.
- W3043001684 countsByYear W30430016842022 @default.
- W3043001684 countsByYear W30430016842023 @default.
- W3043001684 crossrefType "journal-article" @default.
- W3043001684 hasAuthorship W3043001684A5016477472 @default.
- W3043001684 hasAuthorship W3043001684A5036922052 @default.
- W3043001684 hasAuthorship W3043001684A5043637238 @default.
- W3043001684 hasAuthorship W3043001684A5047203788 @default.
- W3043001684 hasAuthorship W3043001684A5071690920 @default.
- W3043001684 hasAuthorship W3043001684A5077816114 @default.
- W3043001684 hasBestOaLocation W30430016841 @default.
- W3043001684 hasConcept C126322002 @default.
- W3043001684 hasConcept C134018914 @default.
- W3043001684 hasConcept C150903083 @default.
- W3043001684 hasConcept C184235292 @default.
- W3043001684 hasConcept C185592680 @default.
- W3043001684 hasConcept C195794163 @default.
- W3043001684 hasConcept C207001950 @default.
- W3043001684 hasConcept C2776174234 @default.
- W3043001684 hasConcept C2777926168 @default.
- W3043001684 hasConcept C2779922275 @default.
- W3043001684 hasConcept C2992814287 @default.
- W3043001684 hasConcept C31903555 @default.
- W3043001684 hasConcept C36020004 @default.
- W3043001684 hasConcept C502942594 @default.
- W3043001684 hasConcept C55493867 @default.
- W3043001684 hasConcept C555293320 @default.
- W3043001684 hasConcept C71924100 @default.