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- W3043003922 endingPage "87" @default.
- W3043003922 startingPage "75" @default.
- W3043003922 abstract "DNA damage challenges both genome integrity and its organization with histone proteins into chromatin, with prominent alterations in histone variant dynamics and histone modifications. While these alterations jeopardize epigenome stability, they are also instrumental for an efficient and timely response to DNA damage. Here, we review recent findings illustrating how histone variants and post-translational modifications actively contribute to and control the DNA damage response. We present accumulating evidence that histone protein changes help relieve the chromatin barrier to DNA repair by regulating chromatin compaction and mobility. We also highlight how histone modifications and variants control transcriptional silencing at damage sites, and we describe both pre-existing and DNA damage-induced chromatin features that govern DNA damage signaling and guide DNA repair pathway choice. We discuss how histone dynamics ultimately participate to the restoration of epigenome integrity and present our current knowledge of key molecular players involved in these critical processes." @default.
- W3043003922 created "2020-07-23" @default.
- W3043003922 creator A5031700171 @default.
- W3043003922 creator A5038882155 @default.
- W3043003922 creator A5048423328 @default.
- W3043003922 date "2021-05-01" @default.
- W3043003922 modified "2023-10-09" @default.
- W3043003922 title "Control of the chromatin response to DNA damage: Histone proteins pull the strings" @default.
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