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- W3043009108 abstract "We investigated the genetic and transcriptional changes associated with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated protein 9 (Cas9) expression in human cancer cell lines. For a subset of cell lines with a wild-type tumor protein TP53 (best known as p53), we detected p53 pathway activation, DNA damage accumulation and emerging p53-inactivating mutations following Cas9 introduction. We discuss the potential implications of our findings in basic and translational research." @default.
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- W3043009108 date "2020-07-14" @default.
- W3043009108 modified "2023-10-16" @default.
- W3043009108 title "Adding to the CASeload: unwarranted p53 signaling induced by Cas9" @default.
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- W3043009108 doi "https://doi.org/10.1080/23723556.2020.1789419" @default.
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