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- W3043014918 abstract "Fe–S clusters function as cofactors of proteins controlling diverse biological processes, such as respiration, photosynthesis, nitrogen fixation, DNA replication, and gene regulation. The mechanism of how Actinobacteria regulate the expression of the sole Fe-S cluster assembly system in response to the various Fe–S cluster demands remains to be elucidated. In this study, we showed that SufR functions as a transcriptional repressor of the sole Fe-S cluster assembly system in the avermectin producer S. avermitilis . [4Fe-4S]-SufR binds to the promoter region of the suf operon and represses its expression. When Fe-S cluster levels are insufficient, SufR loses its [4Fe-4S] cluster and DNA-binding activity. Apo-SufR dissociates from the promoter region of suf operon, and the expression of the suf system is strongly increased by derepression to promote the synthesis of Fe-S clusters. The study clarifies how Streptomyces maintains its Fe-S cluster homeostasis through the activity of SufR to modulate the various Fe-S cluster demands." @default.
- W3043014918 created "2020-07-23" @default.
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- W3043014918 date "2020-09-01" @default.
- W3043014918 modified "2023-10-07" @default.
- W3043014918 title "SufR, a [4Fe-4S] Cluster-Containing Transcription Factor, Represses the <i>sufRBDCSU</i> Operon in Streptomyces avermitilis Iron-Sulfur Cluster Assembly" @default.
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- W3043014918 doi "https://doi.org/10.1128/aem.01523-20" @default.
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