Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043072781> ?p ?o ?g. }
- W3043072781 endingPage "682" @default.
- W3043072781 startingPage "682" @default.
- W3043072781 abstract "Generally, topically applied eye drops have low bioavailability due to short residence time and low penetration of the drug. The aim of the present study was to incorporate dexamethasone (DXM) into nano lipid carriers (NLC), which contain mucoadhesive polymer, in order to increase the bioavailability of the drug. A 23 factorial experimental design was applied, in which the three factors were the polymer, the DXM, and the emulsifier concentrations. The samples were analyzed for particle size, zeta potential, polydispersity index, and Span value. The significant factors were identified. The biocompatibility of the formulations was evaluated with human corneal toxicity tests and immunoassay analysis. The possible increase in bioavailability was analyzed by means of mucoadhesivity, in vitro drug diffusion, and different penetration tests, such as in vitro cornea PAMPA model, human corneal cell penetration, and ex vivo porcine corneal penetration using Raman mapping. The results indicated that DXM can be incorporated in stable mucoadhesive NLC systems, which are non-toxic and do not have any harmful effect on cell junctions. Mucoadhesive NLCs can create a depot on the surface of the cornea, which can predict improved bioavailability." @default.
- W3043072781 created "2020-07-23" @default.
- W3043072781 creator A5015024546 @default.
- W3043072781 creator A5022577543 @default.
- W3043072781 creator A5026142517 @default.
- W3043072781 creator A5033378289 @default.
- W3043072781 creator A5051861289 @default.
- W3043072781 creator A5051973406 @default.
- W3043072781 creator A5062372069 @default.
- W3043072781 creator A5073525177 @default.
- W3043072781 creator A5076058655 @default.
- W3043072781 creator A5078484659 @default.
- W3043072781 creator A5079524348 @default.
- W3043072781 creator A5081907342 @default.
- W3043072781 date "2020-07-20" @default.
- W3043072781 modified "2023-09-29" @default.
- W3043072781 title "Development and Characterization of Potential Ocular Mucoadhesive Nano Lipid Carriers Using Full Factorial Design" @default.
- W3043072781 cites W1531237901 @default.
- W3043072781 cites W1537855055 @default.
- W3043072781 cites W1967915855 @default.
- W3043072781 cites W1969159080 @default.
- W3043072781 cites W1974193226 @default.
- W3043072781 cites W1975356090 @default.
- W3043072781 cites W1976878390 @default.
- W3043072781 cites W1983184770 @default.
- W3043072781 cites W1988806506 @default.
- W3043072781 cites W2011267269 @default.
- W3043072781 cites W2021554667 @default.
- W3043072781 cites W2025582103 @default.
- W3043072781 cites W2054055267 @default.
- W3043072781 cites W2060320802 @default.
- W3043072781 cites W2086302743 @default.
- W3043072781 cites W2090472837 @default.
- W3043072781 cites W2155333783 @default.
- W3043072781 cites W2168459754 @default.
- W3043072781 cites W2463744290 @default.
- W3043072781 cites W2507908121 @default.
- W3043072781 cites W2547063904 @default.
- W3043072781 cites W2572308911 @default.
- W3043072781 cites W2605966271 @default.
- W3043072781 cites W2804518771 @default.
- W3043072781 cites W2905574098 @default.
- W3043072781 cites W2914891586 @default.
- W3043072781 cites W2947293085 @default.
- W3043072781 cites W2995563543 @default.
- W3043072781 cites W3021644704 @default.
- W3043072781 cites W3025422232 @default.
- W3043072781 doi "https://doi.org/10.3390/pharmaceutics12070682" @default.
- W3043072781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7408368" @default.
- W3043072781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32698334" @default.
- W3043072781 hasPublicationYear "2020" @default.
- W3043072781 type Work @default.
- W3043072781 sameAs 3043072781 @default.
- W3043072781 citedByCount "13" @default.
- W3043072781 countsByYear W30430727812021 @default.
- W3043072781 countsByYear W30430727812022 @default.
- W3043072781 countsByYear W30430727812023 @default.
- W3043072781 crossrefType "journal-article" @default.
- W3043072781 hasAuthorship W3043072781A5015024546 @default.
- W3043072781 hasAuthorship W3043072781A5022577543 @default.
- W3043072781 hasAuthorship W3043072781A5026142517 @default.
- W3043072781 hasAuthorship W3043072781A5033378289 @default.
- W3043072781 hasAuthorship W3043072781A5051861289 @default.
- W3043072781 hasAuthorship W3043072781A5051973406 @default.
- W3043072781 hasAuthorship W3043072781A5062372069 @default.
- W3043072781 hasAuthorship W3043072781A5073525177 @default.
- W3043072781 hasAuthorship W3043072781A5076058655 @default.
- W3043072781 hasAuthorship W3043072781A5078484659 @default.
- W3043072781 hasAuthorship W3043072781A5079524348 @default.
- W3043072781 hasAuthorship W3043072781A5081907342 @default.
- W3043072781 hasBestOaLocation W30430727811 @default.
- W3043072781 hasConcept C105795698 @default.
- W3043072781 hasConcept C11432220 @default.
- W3043072781 hasConcept C118487528 @default.
- W3043072781 hasConcept C136229726 @default.
- W3043072781 hasConcept C155672457 @default.
- W3043072781 hasConcept C169222746 @default.
- W3043072781 hasConcept C171250308 @default.
- W3043072781 hasConcept C178790620 @default.
- W3043072781 hasConcept C181389837 @default.
- W3043072781 hasConcept C185592680 @default.
- W3043072781 hasConcept C192562407 @default.
- W3043072781 hasConcept C202751555 @default.
- W3043072781 hasConcept C26291073 @default.
- W3043072781 hasConcept C2776882836 @default.
- W3043072781 hasConcept C2777230088 @default.
- W3043072781 hasConcept C2777625524 @default.
- W3043072781 hasConcept C33923547 @default.
- W3043072781 hasConcept C42475967 @default.
- W3043072781 hasConcept C43617362 @default.
- W3043072781 hasConcept C55493867 @default.
- W3043072781 hasConcept C71924100 @default.
- W3043072781 hasConcept C80107235 @default.
- W3043072781 hasConcept C86181022 @default.
- W3043072781 hasConcept C98274493 @default.
- W3043072781 hasConceptScore W3043072781C105795698 @default.
- W3043072781 hasConceptScore W3043072781C11432220 @default.
- W3043072781 hasConceptScore W3043072781C118487528 @default.