FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043078260> ?p ?o ?g. }

• W3043078260 abstract "Chronic inflammation is involved in the pathogenesis of several metabolic diseases, such as obesity and type 2 diabetes mellitus (T2DM). With the recent worldwide outbreak of coronavirus disease (SARS-CoV-2), it has been observed that individuals with these metabolic diseases are more likely to develop complications, increasing the severity of the disease and a poorer outcome. Coronavirus infection leads to the activation of adaptive and innate immune responses, resulting in massive inflammation (to so called cytokine storm), which in turn can lead to damage to various tissues, septic shock and multiple organ failure. Recent evidence suggests that the common link between metabolic diseases and SARS-CoV-2 is the inflammatory response (chronic/low-grade for metabolic diseases and acute/intense in coronavirus infection). However, the ability of the infected individuals to resolve the inflammation has not yet been explored. The heat shock response (HSR), an important anti-inflammatory pathway, is reduced in patients with metabolic diseases and, consequently, may impair inflammation resolution and control in patients with SARS-CoV-2, thus enabling its amplification and propagation through all tissues. Herein, we present a new hypothesis that aims to explain the increased severity of SARS-CoV-2 infection in people with metabolic diseases, and the possible benefits of HSR-inducing therapies to improve the inflammatory profile in these patients." @default.
• W3043078260 created "2020-07-23" @default.
• W3043078260 creator A5027292626 @default.
• W3043078260 creator A5030902764 @default.
• W3043078260 creator A5048466377 @default.
• W3043078260 date "2020-07-16" @default.
• W3043078260 modified "2023-10-11" @default.
• W3043078260 title "Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications?" @default.
• W3043078260 cites W1525864426 @default.
• W3043078260 cites W1567911976 @default.
• W3043078260 cites W1599595176 @default.
• W3043078260 cites W1977295092 @default.
• W3043078260 cites W1977672942 @default.
• W3043078260 cites W1980897394 @default.
• W3043078260 cites W1987296896 @default.
• W3043078260 cites W1992586784 @default.
• W3043078260 cites W1998377463 @default.
• W3043078260 cites W2000490904 @default.
• W3043078260 cites W2003005406 @default.
• W3043078260 cites W2003667600 @default.
• W3043078260 cites W2010267413 @default.
• W3043078260 cites W2010470984 @default.
• W3043078260 cites W2012248291 @default.
• W3043078260 cites W2013781597 @default.
• W3043078260 cites W2014415555 @default.
• W3043078260 cites W2019036876 @default.
• W3043078260 cites W2031793125 @default.
• W3043078260 cites W2035677139 @default.
• W3043078260 cites W2037587089 @default.
• W3043078260 cites W2045009861 @default.
• W3043078260 cites W2067283691 @default.
• W3043078260 cites W2078629560 @default.
• W3043078260 cites W2079278196 @default.
• W3043078260 cites W2079588664 @default.
• W3043078260 cites W2084299228 @default.
• W3043078260 cites W2089865544 @default.
• W3043078260 cites W2092985720 @default.
• W3043078260 cites W2102214681 @default.
• W3043078260 cites W2106877484 @default.
• W3043078260 cites W2114945345 @default.
• W3043078260 cites W2126919962 @default.
• W3043078260 cites W2128923889 @default.
• W3043078260 cites W2136086564 @default.
• W3043078260 cites W2144153442 @default.
• W3043078260 cites W2168270396 @default.
• W3043078260 cites W2517182034 @default.
• W3043078260 cites W2766899380 @default.
• W3043078260 cites W2808967785 @default.
• W3043078260 cites W2883932351 @default.
• W3043078260 cites W2887502499 @default.
• W3043078260 cites W2892671094 @default.
• W3043078260 cites W2937833908 @default.
• W3043078260 cites W3001897055 @default.
• W3043078260 cites W3008827533 @default.
• W3043078260 cites W3009314935 @default.
• W3043078260 cites W3009885589 @default.
• W3043078260 cites W3012421327 @default.
• W3043078260 cites W3012655019 @default.
• W3043078260 cites W3013283620 @default.
• W3043078260 cites W3014294089 @default.
• W3043078260 cites W3015493613 @default.
• W3043078260 cites W3020601243 @default.
• W3043078260 cites W3030855815 @default.
• W3043078260 cites W3033606323 @default.
• W3043078260 cites W643962955 @default.
• W3043078260 doi "https://doi.org/10.1186/s13098-020-00572-w" @default.
• W3043078260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7364287" @default.
• W3043078260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32690985" @default.
• W3043078260 hasPublicationYear "2020" @default.
• W3043078260 type Work @default.
• W3043078260 sameAs 3043078260 @default.
• W3043078260 citedByCount "25" @default.
• W3043078260 countsByYear W30430782602020 @default.
• W3043078260 countsByYear W30430782602021 @default.
• W3043078260 countsByYear W30430782602022 @default.
• W3043078260 countsByYear W30430782602023 @default.
• W3043078260 crossrefType "journal-article" @default.
• W3043078260 hasAuthorship W3043078260A5027292626 @default.
• W3043078260 hasAuthorship W3043078260A5030902764 @default.
• W3043078260 hasAuthorship W3043078260A5048466377 @default.
• W3043078260 hasBestOaLocation W30430782601 @default.
• W3043078260 hasConcept C116675565 @default.
• W3043078260 hasConcept C126322002 @default.
• W3043078260 hasConcept C134018914 @default.
• W3043078260 hasConcept C159047783 @default.
• W3043078260 hasConcept C203014093 @default.
• W3043078260 hasConcept C2776914184 @default.
• W3043078260 hasConcept C2777628635 @default.
• W3043078260 hasConcept C2777648638 @default.
• W3043078260 hasConcept C2778384902 @default.
• W3043078260 hasConcept C2779134260 @default.
• W3043078260 hasConcept C2779559532 @default.
• W3043078260 hasConcept C2780942790 @default.
• W3043078260 hasConcept C2910068830 @default.
• W3043078260 hasConcept C3008058167 @default.
• W3043078260 hasConcept C524204448 @default.
• W3043078260 hasConcept C555293320 @default.
• W3043078260 hasConcept C60644358 @default.
• W3043078260 hasConcept C71924100 @default.
• W3043078260 hasConcept C86803240 @default.

• next