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- W3043085161 abstract "The gut-brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (Aβ), the pathogenic peptide associated with Alzheimer's disease (AD), seeded by FapC amyloid fragments (FapCS) of Pseudomonas aeruginosa that colonizes the gut microbiome through infections are examined. FapCS display favorable binding with Aβ and a catalytic capacity in seeding the peptide amyloidosis. Upon seeding, twisted Aβ fibrils assume a much-shortened periodicity approximating that of FapC fibrils, accompanied by a 37% sharp rise in the fibrillar diameter, compared with the control. The robust seeding capacity for Aβ by FapCS and the biofilm fragments derived from P. aeruginosa entail abnormal behavior pathology and immunohistology, as well as impaired cognitive function of zebrafish. Together, the data offer the first concrete evidence of structural integration and inheritance in peptide cross-seeding, a crucial knowledge gap in understanding the pathological correlations between different amyloid diseases. The catalytic role of infectious bacteria in promoting Aβ amyloidosis may be exploited as a potential therapeutic target, while the altered mesoscopic signatures of Aβ fibrils may serve as a prototype for molecular assembly and a biomarker for screening bacterial infections in AD." @default.
- W3043085161 created "2020-07-23" @default.
- W3043085161 creator A5002417481 @default.
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- W3043085161 date "2020-07-16" @default.
- W3043085161 modified "2023-10-14" @default.
- W3043085161 title "Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC" @default.
- W3043085161 cites W10948360 @default.
- W3043085161 cites W1531667149 @default.
- W3043085161 cites W1546703330 @default.
- W3043085161 cites W17336797 @default.
- W3043085161 cites W1847069914 @default.
- W3043085161 cites W1889306845 @default.
- W3043085161 cites W1969465952 @default.
- W3043085161 cites W1970280950 @default.
- W3043085161 cites W1973166472 @default.
- W3043085161 cites W1981239255 @default.
- W3043085161 cites W1982273154 @default.
- W3043085161 cites W1992156778 @default.
- W3043085161 cites W1995281235 @default.
- W3043085161 cites W1997081774 @default.
- W3043085161 cites W1999385317 @default.
- W3043085161 cites W2001127343 @default.
- W3043085161 cites W2007523574 @default.
- W3043085161 cites W2008708467 @default.
- W3043085161 cites W2008884445 @default.
- W3043085161 cites W2013322269 @default.
- W3043085161 cites W2019863741 @default.
- W3043085161 cites W2026727321 @default.
- W3043085161 cites W2030325989 @default.
- W3043085161 cites W2031014005 @default.
- W3043085161 cites W2034563015 @default.
- W3043085161 cites W2041418306 @default.
- W3043085161 cites W2041479217 @default.
- W3043085161 cites W2041511735 @default.
- W3043085161 cites W2043274894 @default.
- W3043085161 cites W2050210746 @default.
- W3043085161 cites W2061820841 @default.
- W3043085161 cites W2064248739 @default.
- W3043085161 cites W2064963539 @default.
- W3043085161 cites W2073449985 @default.
- W3043085161 cites W2079699172 @default.
- W3043085161 cites W2082429191 @default.
- W3043085161 cites W2082694975 @default.
- W3043085161 cites W2085242996 @default.
- W3043085161 cites W2085899859 @default.
- W3043085161 cites W2093894883 @default.
- W3043085161 cites W2094135937 @default.
- W3043085161 cites W2097758424 @default.
- W3043085161 cites W2099514643 @default.
- W3043085161 cites W2104700141 @default.
- W3043085161 cites W2107696550 @default.
- W3043085161 cites W2108938583 @default.
- W3043085161 cites W2110792675 @default.
- W3043085161 cites W2113460967 @default.
- W3043085161 cites W2113822705 @default.
- W3043085161 cites W2120653133 @default.
- W3043085161 cites W2120767803 @default.
- W3043085161 cites W2121779716 @default.
- W3043085161 cites W2124316420 @default.
- W3043085161 cites W2126204990 @default.
- W3043085161 cites W2129507901 @default.
- W3043085161 cites W2131805989 @default.
- W3043085161 cites W2136827837 @default.
- W3043085161 cites W2144049496 @default.
- W3043085161 cites W2164057608 @default.
- W3043085161 cites W2168334242 @default.
- W3043085161 cites W2178165437 @default.
- W3043085161 cites W225152533 @default.
- W3043085161 cites W2255595836 @default.
- W3043085161 cites W2332299887 @default.
- W3043085161 cites W2506191739 @default.
- W3043085161 cites W2538431692 @default.
- W3043085161 cites W2600656194 @default.
- W3043085161 cites W2604359737 @default.
- W3043085161 cites W2605968366 @default.
- W3043085161 cites W2735416135 @default.
- W3043085161 cites W2742302497 @default.
- W3043085161 cites W2766612491 @default.
- W3043085161 cites W2769484570 @default.
- W3043085161 cites W2777995939 @default.
- W3043085161 cites W2779718584 @default.
- W3043085161 cites W2805466047 @default.
- W3043085161 cites W2806415037 @default.
- W3043085161 cites W2885344563 @default.
- W3043085161 cites W2890105461 @default.
- W3043085161 cites W2894068917 @default.
- W3043085161 cites W2898599254 @default.
- W3043085161 cites W2899046125 @default.
- W3043085161 cites W2901404890 @default.
- W3043085161 cites W2906268907 @default.