FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043102574> ?p ?o ?g. }

• W3043102574 endingPage "e6" @default.
• W3043102574 startingPage "e3" @default.
• W3043102574 abstract "A 48-year-old-female was diagnosed with SARS-CoV-2 infection by reverse-transcriptase-polymerase-chain-reaction. One day later, she experienced an episode of acute typical chest pain and was transferred to our hospital due to elevated cardiac enzymes (high-sensitivity Troponin-T: 542,6 ng/l (reference upper level (RUL): 14 ng/l) and creatine kinase (CK): 226 U/l (RUL: 170 U/l). Electrocardiogram showed intermittent negative T-waves in inferior leads (II, III, aVF, V4 and V5) matching with inferior wall motion abnormalities in transthoracic echocardiography, leading to the diagnosis of non ST-elevation myocardial infarction (NSTEMI). C-reactive protein, interleukin-6, neopterin, procalcitonin and blood count were normal. Coronary ECG-gated computed tomography angiography (CTA) ruled out coronary stenosis >50% but showed midventricular systolic constriction (Movie 1) without apical ballooning. Subendocardial myocardial perfusion defects were found in multiple myocardial segments (Fig. 1) representing typical imaging findings for myocardial infarction with non-obstructive coronary arteries (MINOCA). Cardiac magnetic resonance imaging (CMR) confirmed subendocardial inferior zonal late enhancement. Coronary CTA (Fig. 2) further showed diffuse irregular vessel walls thickening and perivascular edema, defined as a perivascular fat attenuation index (FAI) of > -70HU, suggestive for vasculitis. There was no typical COVID-19 pulmonary involvement. The patient was treated with acetylsalicylic acid and clopidogrel. Cardiac enzymes declined after 2 days and she was discharged asymptomatic after 6 days.Fig. 2Coronary CTA findings suggestive for vasculitis: Right coronary artery (RCA) with diffuse irregular vessel walls, narrowing with less than 50% stenosis (white arrow, left) and isodense wall thickening (yellow arrow). Perivascular edema was diagnosed by quantifying a perivascular fat attenuation index (FAI) of −45HU on a cross sectional image (upper right). Diffuse narrowing of distal RCA (left, purple arrow) causing inferior and inferoseptal myocardial hypoperfusion (right, white arrow). Mild pericardial fluid collection suggesting mild pericardial effusion (PCE) (purple arrow). Left anterior descending (LAD) artery showed proximal ectasia, mild vessel wall irregularities and perivascular edema (FAI -55HU). CX = circumflex artery. RCA, LAD and CX are shown by curved multiplanar reformations (cMPR). (SyngoVIA™, Siemens). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Myocardial damage during SARS-CoV-2 infection occurs in 8–12%1Lippi G. Lavie C.J. Sanchis-Gomar F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a meta-analysis.Prog Cardiovasc Dis. 2020 Mar 10; (pii: S0033-0620(20)30055-4)Crossref Scopus (485) Google Scholar and more commonly, during severe clinical courses. In our patient, symptoms were mild and CTA-images showed midventricular systolic constriction but without apical ballooning. Multiple zonal subendocardial myocardial perfusion defects were present but no coronary stenosis >50%, suggesting MINOCA, which was confirmed by CMR late-enhancement. CMR ruled out myocarditis. Invasive coronary angiography was avoided. Further, CTA showed signs of vasculitis with diffuse wall irregularities and focal thickening, which may trigger endothelial dysfunction and vasospasm. Perivascular edema was quantified by coronary CTA using the fat-attenuation-index (FAI)3Oikonomou E.K. Marwan M. Desai M.Y. et al.Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data.Lancet. 2018; 392: 929-939Abstract Full Text Full Text PDF PubMed Scopus (466) Google Scholar, which was >-70 HU and as well supports the presence of perivascular inflammation. SARS-CoV-2 may infect the endothelium over ACE-2 receptors. Viral elements within endothelial cells and inflammatory cell death were recently confirmed on pathohistology.2Varga Z. Flammer A.J. Steiger P. et al.Endothelial cell infection and endotheliitis in COVID-19.Lancet. 2020; 395: 1417-1418Abstract Full Text Full Text PDF PubMed Scopus (4189) Google Scholar In addition, SARS-CoV-2 has been linked with procoagulative states and hence may favor microvascular thrombosis, which represents a further possible cause of MINOCA. In summary, coronary CTA was a useful imaging modality in our patient with NSTEMI and SARS-CoV-2 infection to avoid invasive angiography. CTA imaging findings should be regarded as “hypothesis-generating” for the initiation of further systematic research studies. •In a 48 year-old-female with myocardial injury and SARS-CoV-2 infection, coronary CTA showed:oMultiple subendocardial myocardial perfusion defects with less than 50% coronary stenosis (MINOCA)oImaging features suggestive of vasculitis, with perivascular edema-defined as fat attenuation index (FAI)> - 70 HU and diffuse as well as focal vessel wall thickening, potential triggers of endothelial dysfunction, vasospasm and microvascular thrombosis.oCTA ruled out coronary stenosis >50% and invasive coronary angiography was avoided. No financial support was received. There is no conflict of interest. There are no disclosures for all authors. The authors declare no conflict of interest. The manuscript has not been submitted elsewhere. The following is the supplementary data to this article:eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI2NGQxNjIwNzk1NWI0N2E0ZDZhMGE0NWZhMDM3NTI2YiIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjk1Mzg4MDQzfQ.imU3di-Hk8_oBB9RZ7kjNQWILhAmLEMrU9dj2syEgREuikeIe7gTJwbbfn-qo7m0C3byDx6kASFdKC5_MLxF2tCx7aMj3lHQdxGB6a_ipuBkVxUojUall1ea2_ZE6HyC57Bop0iwlYsW_5Wz97cciz0Pkt7Mz3lwVqZC6_Q8YjjNXl-2F5cBI7YqMiNXKwlpO2UMiAOW3ip_WfYqKDZ69bpG7ljIkMQ3V01LkF5MrY9vfl_pfaguEIJAZw1wnmFoh5klkigsemhZWg8SRSZGxCfK9ez2U2Ko3oRUQ8_HPs5cRNkSOGnzYh30HLqO9zxkVBN3baxKEIwsGGmlm7jXJw Download .mp4 (1.67 MB) Help with .mp4 files Multimedia component 1eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiIwZDc1YWI4ODRlM2Q4NjRiNmRkMmU2NGY1MzgzODdmNCIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjk1Mzg4MDQzfQ.gnVzIlw-tP0cWt2_n0Jp_FlidTpBtwijcyQ_gNdhL9NDTCcsN6WWQ9Km5-rbNuP3zSUaW3CmFP9auvFkF6Lznqmor-PgkjYbrYeCEW6gaIhkFwp8p4YepRfNNhb-E8CyvmRfXFFUxDZTtbeusu9sOnb4Iad7f5jSRHzuasbNVsX5vBhfIeTB_YlWZjteoFZt3IsBWTx2CwmGcy-WbZQQUWdqrEG9AqykB09ypcF0qF0_DlEB9XXBKPdiAOQTK4LbKijH8xauisQ5yZTfl5dYUmH7TxTYnDnigQ-Omj8_cy9fUYu7r0DJ6kXCDI-ew8vcgEhIB_rpYdmr4zPmNdPaVg Download .mp4 (0.72 MB) Help with .mp4 files Multimedia component 2" @default.
• W3043102574 created "2020-07-23" @default.
• W3043102574 creator A5019897080 @default.
• W3043102574 creator A5064315512 @default.
• W3043102574 creator A5067202090 @default.
• W3043102574 creator A5077695546 @default.
• W3043102574 creator A5078581977 @default.
• W3043102574 creator A5088148685 @default.
• W3043102574 creator A5088842642 @default.
• W3043102574 date "2021-01-01" @default.
• W3043102574 modified "2023-10-06" @default.
• W3043102574 title "Myocardial injury in COVID-19: The role of coronary computed tomography angiography (CTA)" @default.
• W3043102574 cites W2888909234 @default.
• W3043102574 cites W3009500736 @default.
• W3043102574 cites W3017125154 @default.
• W3043102574 doi "https://doi.org/10.1016/j.jcct.2020.07.002" @default.
• W3043102574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7367010" @default.
• W3043102574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32747170" @default.
• W3043102574 hasPublicationYear "2021" @default.
• W3043102574 type Work @default.
• W3043102574 sameAs 3043102574 @default.
• W3043102574 citedByCount "11" @default.
• W3043102574 countsByYear W30431025742021 @default.
• W3043102574 countsByYear W30431025742022 @default.
• W3043102574 countsByYear W30431025742023 @default.
• W3043102574 crossrefType "journal-article" @default.
• W3043102574 hasAuthorship W3043102574A5019897080 @default.
• W3043102574 hasAuthorship W3043102574A5064315512 @default.
• W3043102574 hasAuthorship W3043102574A5067202090 @default.
• W3043102574 hasAuthorship W3043102574A5077695546 @default.
• W3043102574 hasAuthorship W3043102574A5078581977 @default.
• W3043102574 hasAuthorship W3043102574A5088148685 @default.
• W3043102574 hasAuthorship W3043102574A5088842642 @default.
• W3043102574 hasBestOaLocation W30431025741 @default.
• W3043102574 hasConcept C126322002 @default.
• W3043102574 hasConcept C126838900 @default.
• W3043102574 hasConcept C143409427 @default.
• W3043102574 hasConcept C164705383 @default.
• W3043102574 hasConcept C2776008845 @default.
• W3043102574 hasConcept C2776820930 @default.
• W3043102574 hasConcept C2777910003 @default.
• W3043102574 hasConcept C2778088351 @default.
• W3043102574 hasConcept C2778704086 @default.
• W3043102574 hasConcept C2778742706 @default.
• W3043102574 hasConcept C3019004856 @default.
• W3043102574 hasConcept C500558357 @default.
• W3043102574 hasConcept C71924100 @default.
• W3043102574 hasConceptScore W3043102574C126322002 @default.
• W3043102574 hasConceptScore W3043102574C126838900 @default.
• W3043102574 hasConceptScore W3043102574C143409427 @default.
• W3043102574 hasConceptScore W3043102574C164705383 @default.
• W3043102574 hasConceptScore W3043102574C2776008845 @default.
• W3043102574 hasConceptScore W3043102574C2776820930 @default.
• W3043102574 hasConceptScore W3043102574C2777910003 @default.
• W3043102574 hasConceptScore W3043102574C2778088351 @default.
• W3043102574 hasConceptScore W3043102574C2778704086 @default.
• W3043102574 hasConceptScore W3043102574C2778742706 @default.
• W3043102574 hasConceptScore W3043102574C3019004856 @default.
• W3043102574 hasConceptScore W3043102574C500558357 @default.
• W3043102574 hasConceptScore W3043102574C71924100 @default.
• W3043102574 hasIssue "1" @default.
• W3043102574 hasLocation W30431025741 @default.
• W3043102574 hasLocation W30431025742 @default.
• W3043102574 hasOpenAccess W3043102574 @default.
• W3043102574 hasPrimaryLocation W30431025741 @default.
• W3043102574 hasRelatedWork W1893811640 @default.
• W3043102574 hasRelatedWork W1984936208 @default.
• W3043102574 hasRelatedWork W2009216424 @default.
• W3043102574 hasRelatedWork W2074208211 @default.
• W3043102574 hasRelatedWork W2172353851 @default.
• W3043102574 hasRelatedWork W2408493744 @default.
• W3043102574 hasRelatedWork W3011000825 @default.
• W3043102574 hasRelatedWork W4240077505 @default.
• W3043102574 hasRelatedWork W4324331664 @default.
• W3043102574 hasRelatedWork W3149320807 @default.
• W3043102574 hasVolume "15" @default.
• W3043102574 isParatext "false" @default.
• W3043102574 isRetracted "false" @default.
• W3043102574 magId "3043102574" @default.
• W3043102574 workType "article" @default.