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- W3043103655 endingPage "330a" @default.
- W3043103655 startingPage "330a" @default.
- W3043103655 abstract "Achieving a comprehensive understanding of the behaviour of proteins is greatly facilitated by the knowledge of their structures, thermodynamics and dynamics. All this information can be provided in an effective manner in terms of structural ensembles. A structural ensemble can be obtained by determining the structures, populations and interconversion rates for all the main states that a protein can occupy. To achieve this goal, integrative methods that combine experimental and computational approaches provide powerful tools. Here we focus on cryo-electron microscopy, which has become over recent years an invaluable resource to bridge the gap from order to disorder in structural biology. In this review, we provide a perspective of the current challenges and opportunities in determining protein structural ensembles using integrative approaches that can combine cryo-electron microscopy data with other available sources of information, along with an overview of the tools available to the community." @default.
- W3043103655 created "2020-07-23" @default.
- W3043103655 creator A5038452125 @default.
- W3043103655 creator A5056483461 @default.
- W3043103655 date "2019-02-01" @default.
- W3043103655 modified "2023-10-16" @default.
- W3043103655 title "Simultaneous Determination of Protein Structure and Dynamics using Cryo-Electron Microscopy" @default.
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- W3043103655 doi "https://doi.org/10.1016/j.bpj.2018.11.1794" @default.
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