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- W3043104639 abstract "Abstract Sudden cardiac death (SCD) is one of the leading causes of death in the nation. Women have an overall lower risk of SCD than men, even after adjusting for risk factors. Even so, SCD remains the fifth leading cause of death in women and the third leading cause of premature death in women. Ventricular tachycardia (VT) and ventricular fibrillation (VF) represent the majority of cardiac arrests and SCD in both men and women. However, women more often present with pulseless electrical activity (PEA) or asystole, are less likely to have witnessed cardiac arrests, and are more likely to arrest at home. This suggests the initial rhythm may have been VT/VF that degenerated to asystole or PEA during the time to arrival of emergency personnel. Ventricular tachycardia (VT) and ventricular fibrillation (VF) represent the majority of cardiac arrests and SCD in both men and women. However, women more often present with pulseless electrical activity (PEA) or asystole, are less likely to have witnessed cardiac arrests, and are more likely to arrest at home. This suggests the initial rhythm may have been VT/VF that degenerated to asystole or PEA during the time to arrival of emergency personnel. Differences in substrate, as well as in hormonal and autonomic influences affect the mechanism of and susceptibility to SCD in women versus men. The most prevalent cause of SCD is coronary artery disease (CAD), and fewer women with epicardial CAD have SCD compared with men. Yet more women with SCD have microvascular disease. Hormonal differences between men and women affect expression and function of ion channels and excitation -contraction coupling. This results in variable susceptibility to ventricular arrhythmias and SCD. Autonomic activity and reactivity also vary between men and women, which results in different arrhythmogenic susceptibility. Known differences in electrophysiological, hormonal, and autonomic properties lead to sex-specific risks for SCD. A greater understanding of the sex-specific mechanisms of SCD will improve risk assessment, care, and outcomes for women at risk of SCD." @default.
- W3043104639 created "2020-07-23" @default.
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- W3043104639 date "2020-01-01" @default.
- W3043104639 modified "2023-09-24" @default.
- W3043104639 title "Sex-specific mechanisms of sudden cardiac death" @default.
- W3043104639 doi "https://doi.org/10.1016/b978-0-12-817728-0.00069-3" @default.
- W3043104639 hasPublicationYear "2020" @default.
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