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• W3043109076 endingPage "3290" @default.
• W3043109076 startingPage "3290" @default.
• W3043109076 abstract "A library of embelin derivatives has been synthesized through a multicomponent reaction from embelin (1), aldehydes and privileged structures such as 4-hydroxycoumarin, 4-hydroxy-2H-pyran-2-one and 2-naphthol, in the presence of InCl3 as catalyst. This multicomponent reaction implies Knoevenagel condensation, Michael addition, intramolecular cyclization and dehydration. Many of the synthesized compounds were active and selective against Gram-positive bacteria, including one important multiresistant Staphylococcus aureus clinical isolate. It was found how the conjugation of diverse privileged substructure with embelin led to adducts having enhanced antibacterial activities." @default.
• W3043109076 created "2020-07-23" @default.
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• W3043109076 date "2020-07-20" @default.
• W3043109076 modified "2023-09-26" @default.
• W3043109076 title "Efficient Multicomponent Synthesis of Diverse Antibacterial Embelin-Privileged Structure Conjugates" @default.
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• W3043109076 doi "https://doi.org/10.3390/molecules25143290" @default.
• W3043109076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7397138" @default.
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• W3043109076 hasPublicationYear "2020" @default.
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