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- W3043113211 endingPage "101623" @default.
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- W3043113211 abstract "High levels of oxidative radicals generated by daily light exposure and high metabolic rate suggest that the antioxidant machinery of the retina and retinal pigment epithelium (RPE) is crucial for their survival. DJ-1 is a redox-sensitive protein that has been shown to have neuroprotective function in the brain in Parkinson's disease and other neurodegenerative diseases. Here, we analyzed the role of DJ-1 in the retina during oxidative stress and aging. We induced low-level oxidative stress in young (3-month-old) and old (15-month-old) C57BL/6J (WT) and DJ-1 knockout (KO) mice and evaluated effects in the RPE and retina. Absence of DJ-1 resulted in increased retinal dysfunction in response to low levels of oxidative stress. Our findings suggest that loss of DJ-1 affects the RPE antioxidant machinery, rendering it unable to combat and neutralize low-level oxidative stress, irrespective of age. Moreover, they draw a parallel to the retinal degeneration observed in AMD, where the occurrence of genetic variants may leave the retina and RPE unable to fight sustained, low-levels of oxidative stress. • Antioxidants are upregulated in young DJ-1 KO RPE but downregulated in the retina. • DJ-1 KO retinas are degenerated under low-level oxidative stress, regardless of age. • Retinas of both young C57BL and DJ-1 KO were able to regulate antioxidant genes upon low-level oxidative stress. • Retinas of both aged C57BL and DJ-1 KO were unable to regulate antioxidant genes upon low-level oxidative stress. • RPE of aged C57BLl mice upregulated some antioxidant genes." @default.
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- W3043113211 date "2020-10-01" @default.
- W3043113211 modified "2023-10-03" @default.
- W3043113211 title "Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1" @default.
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- W3043113211 doi "https://doi.org/10.1016/j.redox.2020.101623" @default.
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