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- W3043125824 endingPage "97" @default.
- W3043125824 startingPage "88" @default.
- W3043125824 abstract "Abstract Excessive gut luminal iron contributes to the initiation and progression of colorectal cancer. However, emerging evidence suggests that reduced iron intake and low systemic iron levels are also associated with the pathogenesis of colorectal cancer. This is important because patients with colorectal cancer often present with iron deficiency. Iron is necessary for appropriate immunological functions; hence, iron deficiency may hinder cancer immunosurveillance and potentially modify the tumor immune microenvironment, both of which may assist cancer development. This is supported by studies showing that patients with colorectal cancer with iron deficiency have inferior outcomes and reduced response to therapy. Here, we provide an overview of the immunological consequences of iron deficiency and suggest ensuring adequate iron therapy to limit these outcomes." @default.
- W3043125824 created "2020-07-23" @default.
- W3043125824 creator A5027807300 @default.
- W3043125824 creator A5062076253 @default.
- W3043125824 creator A5075268369 @default.
- W3043125824 date "2020-07-17" @default.
- W3043125824 modified "2023-10-15" @default.
- W3043125824 title "Iron deficiency, immunology, and colorectal cancer" @default.
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