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• W3043133628 abstract "In the main olfactory epithelium (MOE), new olfactory sensory neurons (OSNs) are persistently generated to replace lost neurons throughout an organism's lifespan. This process predominantly depends on the proliferation of globose basal cells (GBCs), the actively dividing stem cells in the MOE. Here, by using CRISPR/Cas9 and RNAi coupled with adeno-associated virus (AAV) nose delivery approaches, we demonstrated that knockdown of miR-200b/a in the MOE resulted in supernumerary Mash1-marked GBCs and decreased numbers of differentiated OSNs, accompanied by abrogation of male behaviors. We further showed that in the MOE, miR-200b/a targets the ten-eleven translocation methylcytosine dioxygenase TET3, which cooperates with RE1-silencing transcription factor (REST) to exert their functions. Deficiencies including proliferation, differentiation, and behaviors illustrated in miR-200b/a knockdown mice were rescued by suppressing either TET3 or REST. Our work describes a mechanism of coordination of GBC proliferation and differentiation in the MOE and olfactory male behaviors through miR-200/TET3/REST signaling." @default.
• W3043133628 created "2020-07-23" @default.
• W3043133628 creator A5018119065 @default.
• W3043133628 creator A5023440365 @default.
• W3043133628 creator A5037382595 @default.
• W3043133628 creator A5053927913 @default.
• W3043133628 creator A5066162156 @default.
• W3043133628 date "2020-07-17" @default.
• W3043133628 modified "2023-10-16" @default.
• W3043133628 title "The micro <scp>RNA</scp> / <scp>TET</scp> 3/ <scp>REST</scp> axis is required for olfactory globose basal cell proliferation and male behavior" @default.
• W3043133628 cites W1483685331 @default.
• W3043133628 cites W1528771346 @default.
• W3043133628 cites W1554330891 @default.
• W3043133628 cites W1562614302 @default.
• W3043133628 cites W1582869095 @default.
• W3043133628 cites W1964186845 @default.
• W3043133628 cites W1968754789 @default.
• W3043133628 cites W1974043282 @default.
• W3043133628 cites W1974178978 @default.
• W3043133628 cites W1974282788 @default.
• W3043133628 cites W1974618036 @default.
• W3043133628 cites W1974950833 @default.
• W3043133628 cites W1975238117 @default.
• W3043133628 cites W1977423612 @default.
• W3043133628 cites W1977709885 @default.
• W3043133628 cites W1980750918 @default.
• W3043133628 cites W1981463058 @default.
• W3043133628 cites W1990689143 @default.
• W3043133628 cites W1996306783 @default.
• W3043133628 cites W2000463303 @default.
• W3043133628 cites W2004836530 @default.
• W3043133628 cites W2009194442 @default.
• W3043133628 cites W2010829205 @default.
• W3043133628 cites W2010852678 @default.
• W3043133628 cites W2014812461 @default.
• W3043133628 cites W2018348038 @default.
• W3043133628 cites W2019631798 @default.
• W3043133628 cites W2023473047 @default.
• W3043133628 cites W2026255880 @default.
• W3043133628 cites W2035898194 @default.
• W3043133628 cites W2038316650 @default.
• W3043133628 cites W2040241605 @default.
• W3043133628 cites W2040977469 @default.
• W3043133628 cites W2041028481 @default.
• W3043133628 cites W2045350939 @default.
• W3043133628 cites W2048772732 @default.
• W3043133628 cites W2064941738 @default.
• W3043133628 cites W2065542336 @default.
• W3043133628 cites W2076398196 @default.
• W3043133628 cites W2077030210 @default.
• W3043133628 cites W2077381938 @default.
• W3043133628 cites W2085114914 @default.
• W3043133628 cites W2086258090 @default.
• W3043133628 cites W2091708438 @default.
• W3043133628 cites W2092921145 @default.
• W3043133628 cites W2101136328 @default.
• W3043133628 cites W2102519175 @default.
• W3043133628 cites W2105037435 @default.
• W3043133628 cites W2107277218 @default.
• W3043133628 cites W2113486281 @default.
• W3043133628 cites W2121845150 @default.
• W3043133628 cites W2124674257 @default.
• W3043133628 cites W2138683224 @default.
• W3043133628 cites W2141759311 @default.
• W3043133628 cites W2144071128 @default.
• W3043133628 cites W2147022658 @default.
• W3043133628 cites W2153932747 @default.
• W3043133628 cites W2155517982 @default.
• W3043133628 cites W2157072099 @default.
• W3043133628 cites W2158649743 @default.
• W3043133628 cites W2162674813 @default.
• W3043133628 cites W2170697668 @default.
• W3043133628 cites W2196662084 @default.
• W3043133628 cites W2224519355 @default.
• W3043133628 cites W2253584908 @default.
• W3043133628 cites W2304268185 @default.
• W3043133628 cites W2324816762 @default.
• W3043133628 cites W2342818826 @default.
• W3043133628 cites W2346657728 @default.
• W3043133628 cites W2354407467 @default.
• W3043133628 cites W2461013690 @default.
• W3043133628 cites W2470528655 @default.
• W3043133628 cites W2510924509 @default.
• W3043133628 cites W2513435395 @default.
• W3043133628 cites W2557367524 @default.
• W3043133628 cites W2567689948 @default.
• W3043133628 cites W2588637030 @default.
• W3043133628 cites W2590310168 @default.
• W3043133628 cites W2606089693 @default.
• W3043133628 cites W2613078538 @default.
• W3043133628 cites W2613706529 @default.
• W3043133628 cites W2615166509 @default.
• W3043133628 cites W2620315774 @default.
• W3043133628 cites W2622163197 @default.
• W3043133628 cites W2732147874 @default.
• W3043133628 cites W2735951677 @default.
• W3043133628 cites W2765658539 @default.
• W3043133628 cites W2768413599 @default.
• W3043133628 cites W2769220533 @default.
• W3043133628 cites W2784635738 @default.

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