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• W3043136211 endingPage "1400" @default.
• W3043136211 startingPage "1400" @default.
• W3043136211 abstract "While the use of topical drops for the delivery of drugs to the anterior of the eye is well accepted, it is far from efficient with as little as 5% of the drug instilled on the eye actually reaching the target tissue. The ability to prolong the residence time on the eye is desirable. Based on the acceptability of 2-hydroxyethyl methacrylate based polymers in contact lens applications, the current work focuses on the development of a poly(2-hydroxyethyl methacrylate (HEMA)) nanoparticle system. The particles were modified to allow for degradation and to permit mucoadhesion. Size and morphological analysis of the final polymer products showed that nano-sized, spherical particles were produced. FTIR spectra demonstrated that the nanoparticles comprised poly(HEMA) and that 3-(acrylamido)phenylboronic acid (3AAPBA), as a mucoadhesive, was successfully incorporated. Degradation of nanoparticles containing N,N′-bis(acryloyl)cystamine (BAC) after incubation with DL-dithiothreitol (DTT) was confirmed by a decrease in turbidity and through transmission electron microscopy (TEM). Nanoparticle mucoadhesion was shown through an in-vitro zeta potential analysis." @default.
• W3043136211 created "2020-07-23" @default.
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• W3043136211 date "2020-07-18" @default.
• W3043136211 modified "2023-09-29" @default.
• W3043136211 title "Mucoadhesive Nanoparticles for Drug Delivery to the Anterior Eye" @default.
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• W3043136211 doi "https://doi.org/10.3390/nano10071400" @default.
• W3043136211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7408143" @default.
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