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• W3043136333 abstract "• Transepithelial ion transport is crucial to maintain the skin homeostasis. • A 30-minutes contact with cisplatin solution is efficient to affect transepithelial ion transport in the skin. • Cisplatin particularly influences the transepithelial transport of chloride, rather than sodium ions. • Cisplatin does not change skin vitality and permeability. Platinum-based drugs, used in treating tumors, cause numerous undesirable effects in patients, like neuropathic pain, hypersensitivity, reddening, pruritus and rash. Changes in Na + transport modify local osmolality and contribute to the initiation of hypersensitivity and allergy. They are also associated with stimulation of C-fibres and hyperalgesia. Cl − transport is essential for regulation of sweat composition and the migration of immunocompetent cells. The aim of the conducted study was to assess the effect of a cisplatin solution on the electrophysiological parameters of the isolated rabbit skin specimens. The difference in transepithelial electrical potential (PD) and resistance (R) in stationary conditions and during 15 s mechanical-chemical stimulation (PDmin and PDmax), were measured. Measurement of R revealed that tissue samples were live, and their permeability to ions were stable. Control specimens had PD -0.22 mV (median). The PD of specimens treated by cisplatin was -0.55 mV (median), to for cisplatin and bumetanide 0 mV (median). Treatment with cisplatin did not change the continuous transport of Na + and K + ions, but did change that of Cl − ions. Stimulation of samples with the transport blockers of Cl − , Na + and both induced repeatable and measurable reactions in the transport of the appropriate ions. It was shown that absorption of Na + ions and release of Cl − ions was intensified than in the untreated specimens. It was proven in the study that cisplatin influences the Na + and Cl − transport in the skin cells. Restoring the balance in ion flow can prevent side effects of use cisplatin-based drugs." @default.
• W3043136333 created "2020-07-23" @default.
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• W3043136333 date "2020-09-01" @default.
• W3043136333 modified "2023-10-05" @default.
• W3043136333 title "Cisplatin influences the skin ion transport – An in vitro study" @default.
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• W3043136333 doi "https://doi.org/10.1016/j.biopha.2020.110502" @default.
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