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• W3043166064 abstract "Abstract In this study, 5-amino-nicotinic acid derivatives ( 1 – 13 ) have been designed and synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase enzymes. The synthesized compounds ( 1 – 13 ) exhibited promising α-amylase and α-glucosidase activities. IC 50 values for α-amylase activity ranged between 12.17 ± 0.14 to 37.33 ± 0.02 µg/mL ± SEM while for α-glucosidase activity the IC 50 values were ranged between 12.01 ± 0.09 to 38.01 ± 0.12 µg/mL ± SEM. In particular, compounds 2 and 4 – 8 demonstrated significant inhibitory activities against α-amylase and α-glucosidase and the inhibitory potential of these compounds was comparable to the standard acarbose (10.98 ± 0.03 and 10.79 ± 0.17 µg/mL ± SEM, respectively). In addition, the impact of substituent on the inhibitory potential of these compounds was assessed to establish structure activity relationships. Studies in molecular simulations were conducted to better comprehend the binding properties of the compounds. All the synthesized compounds were extensively characterized with modern spectroscopic methods including 1 H-NMR, 13 C–NMR, FTIR, HR-MS and elemental analysis." @default.
• W3043166064 created "2020-07-23" @default.
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• W3043166064 date "2020-07-14" @default.
• W3043166064 modified "2023-10-12" @default.
• W3043166064 title "Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives" @default.
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• W3043166064 doi "https://doi.org/10.1186/s13065-020-00695-1" @default.
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